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Anti-Siglec-3/CD33 Antibody (7L591)

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Anti-Siglec-3/CD33 Antibody (7L591)
产品编号 TMAY-02292
别名 Siglec-3, SIGLEC3, p67, CD33 molecule

Anti-Siglec-3/CD33 Antibody (7L591) 是一种 Rabbit 抗体，靶向 Siglec-3/CD33。Anti-Siglec-3/CD33 Antibody (7L591) 可用于 ELISA,FCM。

Anti-Siglec-3/CD33 Antibody (7L591)
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Anti-Siglec-3/CD33 Antibody (7L591)

Rating icon 还可以
Anti-Siglec-3/CD33 Antibody (7L591)
产品编号 TMAY-02292 别名 Siglec-3, SIGLEC3, p67, CD33 molecule

Anti-Siglec-3/CD33 Antibody (7L591) 是一种 Rabbit 抗体，靶向 Siglec-3/CD33。Anti-Siglec-3/CD33 Antibody (7L591) 可用于 ELISA,FCM。

规格价格库存数量
100 μL
¥ 2,279
5日内发货
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产品介绍

生物活性
产品描述
Anti-Siglec-3/CD33 Antibody (7L591) is a Rabbit antibody targeting Siglec-3/CD33. Anti-Siglec-3/CD33 Antibody (7L591) can be used in ELISA,FCM.
别名Siglec-3, SIGLEC3, p67, CD33 molecule
Ig Type
Rabbit IgG
克隆号
7L591
交叉反应
Human
验证活性
Flow cytometric analysis of Human CD33 expression on human whole blood monocytes. Cells were stained with purified anti-Human CD33, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable monocytes.
应用
ELISA,FCM
推荐剂量
ELISA: 1:5000-1:10000; FCM: 1:25-1:100
抗体种类
Monoclonal
宿主来源Rabbit
构建方式This antibody was obtained from a rabbit immunized with purified, recombinant Human CD33 / Siglec-3 (rh CD33 / Siglec-3; TMPY-03805; AAH28152.1; Met1-His259).
纯化方式Protein A
性状Liquid
缓冲液0.2 μm filtered solution in PBS
研究背景Myeloid cell surface antigen CD33 also known as Sialic acid binding Ig-like lectin 3, CD33 antigen or Siglec-3, is a member of the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. This Single-pass type I membrane protein contains 1 Ig-like C2-type (immunoglobulin-like) domain and 1 Ig-like V-type (immunoglobulin-like) domain. CD33 /Siglec-3 is a putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. CD33 /Siglec-3 preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. CD33/Siglec-3 induces apoptosis in acute myeloid leukemia (in vitro). CD33/Siglec-3 can function as a sialic acid-dependent cell adhesion molecule and that binding can be modulated by endogenous sialoglycoconjugates when CD33 is expressed in a plasma membrane.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
偶联与修饰
偶联
Unconjugated
其他可选修饰符
APC/PerCP/FITC/PE
可提供抗体种类
5
抗原信息
免疫原
Recombinant Protein: Human CD33 / Siglec-3 Protein (TMPY-03805)
抗原种属
Human
研究领域
Cancer Drug Targets, ITIM/ITAM Immunoreceptors and Related Molecules
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.

计算器

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关键词

SIGLEC 3

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