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Anti-Siglec-2/CD22 Antibody-FITC (1M79)
还可以产品编号 TMAY-02165F
Anti-Siglec-2/CD22 Antibody-FITC (1M79) 是一种 FITC-conjugated Mouse 抗体，靶向 Siglec-2/CD22。Anti-Siglec-2/CD22 Antibody-FITC (1M79) 可用于 FCM。
Anti-Siglec-2/CD22 Antibody-FITC (1M79)
Anti-Siglec-2/CD22 Antibody-FITC (1M79)
还可以产品编号 TMAY-02165F
Anti-Siglec-2/CD22 Antibody-FITC (1M79) 是一种 FITC-conjugated Mouse 抗体，靶向 Siglec-2/CD22。Anti-Siglec-2/CD22 Antibody-FITC (1M79) 可用于 FCM。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-Siglec-2/CD22 Antibody-FITC (1M79) is a FITC-conjugated Mouse antibody targeting Siglec-2/CD22. Anti-Siglec-2/CD22 Antibody-FITC (1M79) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 1M79 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of Human CD22 expression on human whole blood lymphocytes. Cells were stained with FITC-conjugated anti-Human CD22 and APC-conjugated anti-Human CD19. The dot plots were derived from gated events with the forward and side light-scatter characteristics of viable lymphocytes. |
| 应用 | FCM |
| 推荐剂量 | 5 μl/Test, 0.1 mg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD22 / Siglec-2 (rh CD22 / Siglec-2; TMPY-02034; P20273-1; Met1-Arg687) and conjugated with FITC under optimum conditions, the unreacted FITC was removed. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| 研究背景 | CD22 is a member of the immunoglobulin superfamily, SIGLEC family of lectins. It is first expressed in the cytoplasm of pro-B and pre-B cells, and on the surface as B cells mature to become IgD+. CD22 serves as an adhesion receptor for sialic acid-bearing ligands expressed on erythrocytes and all leukocyte classes. In addition to its potential role as a mediator of intercellular interactions, signal transduction through CD22 can activate B cells and modulate antigen receptor signaling in vitro. The phenotype of CD22-deficient mice suggests that CD22 is primarily involved in the generation of mature B cells within the bone marrow, blood, and marginal zones of lymphoid tissues. CD22 recruits the tyrosine phosphatase Src homology 2 domain-containing phosphatase 1 (SHP-1) to immunoreceptor tyrosine-based inhibitory motifs (ITIMs) and inhibits B-cell receptor (BCR)-induced Ca2+ signaling on normal B cells. CD22 interacts specifically with ligands carrying alpha2-6-linked sialic acids. As an inhibitory coreceptor of the B-cell receptor (BCR), CD22 plays a critical role in establishing signalling thresholds for B-cell activation. Like other coreceptors, the ability of CD22 to modulate B-cell signalling is critically dependent upon its proximity to the BCR, and this in turn is governed by the binding of its extracellular domain to alpha2,6-linked sialic acid ligands. However, genetic studies in mice reveal that some CD22 functions are regulated by ligand binding, whereas other functions are ligand-independent and may only require expression of an intact CD22 cytoplasmic domain at the B-cell surface. CD19 regulates CD22 phosphorylation by augmenting Lyn kinase activity, while CD22 inhibits CD19 phosphorylation via SHP-1.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| 偶联 | FITC |
| 其他可选修饰符 | Unconjugated/PerCP/PE |
| 可提供抗体种类 | 4 |
| 免疫原 | Recombinant Human CD22 / Siglec-2 Protein (TMPY-02034) |
| 抗原种属 | Human |
| 研究领域 | Cancer Drug Targets, ITIM/ITAM Immunoreceptors and Related Molecules |
存储&运输
| 储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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