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顶部生物活性储存和溶解信息计算器

Anti-Siglec-2/CD22 Antibody (3K479)

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产品编号 TMAY-03563

别名 SIGLEC-2, SIGLEC2, CD22 molecule

Anti-Siglec-2/CD22 Antibody (3K479) 是一种 Rabbit 抗体，靶向 Siglec-2/CD22。Anti-Siglec-2/CD22 Antibody (3K479) 可用于 FCM。

Anti-Siglec-2/CD22 Antibody (3K479)

Anti-Siglec-2/CD22 Antibody (3K479)

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产品编号 TMAY-03563 别名 SIGLEC-2, SIGLEC2, CD22 molecule

Anti-Siglec-2/CD22 Antibody (3K479) 是一种 Rabbit 抗体，靶向 Siglec-2/CD22。Anti-Siglec-2/CD22 Antibody (3K479) 可用于 FCM。

规格价格库存数量
100 μL
¥ 2,279
5日内发货
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产品介绍

生物活性
产品描述
Anti-Siglec-2/CD22 Antibody (3K479) is a Rabbit antibody targeting Siglec-2/CD22. Anti-Siglec-2/CD22 Antibody (3K479) can be used in FCM.
别名SIGLEC-2, SIGLEC2, CD22 molecule
Ig Type
Rabbit IgG
克隆号
3K479
交叉反应
Mouse
特异性
Mouse Siglec-2/CD22
验证活性
Flow cytometric analysis of Mouse CD22 expression on BABL/c splenocytes. Cells were stained with purified anti-Mouse CD22, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
应用FCM
推荐剂量
FCM: 1:25-1:100
抗体种类
Monoclonal
宿主来源Rabbit
构建方式This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD22 (rM CD22; TMPY-04083; BAE33829.1; Met1-Arg708).
纯化方式Protein A
性状Liquid
缓冲液0.2 μm filtered solution in PBS
研究背景CD22 is a member of the immunoglobulin superfamily, SIGLEC family of lectins. It is first expressed in the cytoplasm of pro-B and pre-B cells, and on the surface as B cells mature to become IgD+. CD22 serves as an adhesion receptor for sialic acid-bearing ligands expressed on erythrocytes and all leukocyte classes. In addition to its potential role as a mediator of intercellular interactions, signal transduction through CD22 can activate B cells and modulate antigen receptor signaling in vitro. The phenotype of CD22-deficient mice suggests that CD22 is primarily involved in the generation of mature B cells within the bone marrow, blood, and marginal zones of lymphoid tissues. CD22 recruits the tyrosine phosphatase Src homology 2 domain-containing phosphatase 1 (SHP-1) to immunoreceptor tyrosine-based inhibitory motifs (ITIMs) and inhibits B-cell receptor (BCR)-induced Ca2+ signaling on normal B cells. CD22 interacts specifically with ligands carrying alpha2-6-linked sialic acids. As an inhibitory coreceptor of the B-cell receptor (BCR), CD22 plays a critical role in establishing signalling thresholds for B-cell activation. Like other coreceptors, the ability of CD22 to modulate B-cell signalling is critically dependent upon its proximity to the BCR, and this in turn is governed by the binding of its extracellular domain to alpha2,6-linked sialic acid ligands. However, genetic studies in mice reveal that some CD22 functions are regulated by ligand binding, whereas other functions are ligand-independent and may only require expression of an intact CD22 cytoplasmic domain at the B-cell surface. CD19 regulates CD22 phosphorylation by augmenting Lyn kinase activity, while CD22 inhibits CD19 phosphorylation via SHP-1.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
偶联与修饰
偶联
Unconjugated
其他可选修饰符
APC/FITC/PE
可提供抗体种类
4
抗原信息
免疫原
Recombinant Protein: Mouse CD22 Protein (TMPY-04083)
抗原种属
Mouse
研究领域
Cancer Drug Targets, ITIM/ITAM Immunoreceptors and Related Molecules
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.

计算器

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关键词

SIGLEC 2

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5.0
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