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顶部产品介绍偶联与修饰抗原信息化学信息储存和溶解信息计算器

Anti-SHH Monoclonal Antibody (4U905)

Synonyms: TPTPS, TPT, SMMCI, MCOPCB5, HPE3, HLP3, HHG1
货号 TMAT-1335 一键复制产品信息
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Anti-SHH Monoclonal Antibody (4U905) 是一种 Mouse 抗体，靶向 SHH。Anti-SHH Monoclonal Antibody (4U905) 可用于 WB,IHC,FCM。

Anti-SHH Monoclonal Antibody (4U905)

一键复制产品信息
Rating icon 还可以
货号 TMAT-1335

别名 TPTPS, TPT, SMMCI, MCOPCB5, HPE3, HLP3, HHG1

Anti-SHH Monoclonal Antibody (4U905) 是一种 Mouse 抗体，靶向 SHH。Anti-SHH Monoclonal Antibody (4U905) 可用于 WB,IHC,FCM。

Anti-SHH Monoclonal Antibody (4U905)
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产品介绍

生物活性
产品描述
Anti-SHH Monoclonal Antibody (4U905) is a Mouse antibody targeting SHH. Anti-SHH Monoclonal Antibody (4U905) can be used in WB,IHC,FCM.
别名
TPTPS, TPT, SMMCI, MCOPCB5, HPE3, HLP3, HHG1
Ig Type
IgG1
克隆号
4U905
反应种属
Human,Mouse,Monkey
应用WBIHCFCM
推荐剂量
WB: 1/500-1/2000; IHC: 1/200-1/1000; FCM: 1/200-1/400
抗体种类
Monoclonal
宿主来源Mouse
构建方式Hybridoma Monoclonal Antibody
纯化方式Purified by protein A or protein G
性状Liquid
缓冲液PBS with 0.05% sodium azide
浓度1 mg/mL
研究背景This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Purified recombinant fragment of human SHH (AA: 26-161) expressed in E. Coli.
抗原种属
Human
基因名称
SHH
基因ID
6469
蛋白名称
Sonic hedgehog protein
Uniprot ID
Q15465
化学信息
分子量Theoretical: 49.6 kDa.
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

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  • 配液 计算器
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