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Anti-Shh Antibody (2T322)

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货号 TMAB-12768

Anti-Shh Antibody (2T322) 是一种 Rabbit 抗体,靶向 Shh。Anti-Shh Antibody (2T322) 可用于 WB,IHC-P,IHC-Fr,ICC/IF,IF,FCM。

Anti-Shh Antibody (2T322)

Anti-Shh Antibody (2T322)

一键复制产品信息
Rating icon 还可以
货号 TMAB-12768

Anti-Shh Antibody (2T322) 是一种 Rabbit 抗体,靶向 Shh。Anti-Shh Antibody (2T322) 可用于 WB,IHC-P,IHC-Fr,ICC/IF,IF,FCM。

规格价格库存数量
25 μL
¥ 790
5日内发货
50 μL
¥ 1,385
5日内发货
100 μL
¥ 2,480
5日内发货
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产品介绍


生物活性
产品描述
Anti-Shh Antibody (2T322) is a Rabbit antibody targeting Shh. Anti-Shh Antibody (2T322) can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF,FCM.
Ig Type
IgG
克隆号
2T322
反应种属
Human
应用WBIHC-PIHC-FrICC/IFIFFCM
推荐剂量
WB: 1:500-2000; IHC-P: 1:50-200; IHC-Fr: 1:50-200; ICC/IF: 1:50-200; IF: 1:50-200; FCM: 1:50-100
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Sonic hedgehog protein C-product: Secreted, extracellular space. Note=The C-terminal peptide diffuses from the cell. Sonic hedgehog protein N-product: Cell membrane; Lipid-anchor. Note=The N-product either remains associated with lipid rafts at the cell surface, or forms freely diffusible active multimers with its hydrophobic lipid-modified N- and C-termini buried inside.
组织特异性Expressed in fetal intestine, liver, lung, and kidney. Not expressed in adult tissues.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究背景The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity).Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity).Both activities occur in the reticulum endoplasmic (By similarity).
抗原信息
免疫原
A synthesized peptide: human Sonic hedgehog protein
抗原种属
Human
基因名称
SHH
基因ID
蛋白名称
Sonic hedgehog protein
Uniprot ID
功能
Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction (By similarity).
化学信息
分子量Theoretical: 50 kDa. Actual: 51 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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