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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-SH3PX1 Polyclonal Antibody

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货号 TMAB-12756

Anti-SH3PX1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 SH3PX1。Anti-SH3PX1 Polyclonal Antibody 可用于 WB。

Anti-SH3PX1 Polyclonal Antibody

Anti-SH3PX1 Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-12756

Anti-SH3PX1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 SH3PX1。Anti-SH3PX1 Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-SH3PX1 Polyclonal Antibody is a Rabbit antibody targeting SH3PX1. Anti-SH3PX1 Polyclonal Antibody can be used in WB.
Ig Type
IgG
反应种属
Mouse (predicted:Human,Rat,Dog,Pig,Cow,Horse)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasmic vesicle membrane. Cell membrane. Cytoplasmic vesicle > clathrin-coated vesicle. Golgi apparatus > trans-Golgi network. Cell projection > ruffle. Cytoplasm. Localized at sites of endocytosis at the cell membrane. Detected on newly formed macropinosomes. Transiently recruited to clathrin-coated pits at a late stage of clathrin-coated vesicle formation. Colocalizes with the actin cytoskeleton at the cell membrane.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Sorting nexin (SNX) proteins are members of a large family of hydrophilic PX (phospholipid-binding motif) domain-containing proteins that interact with a variety of receptor types. SNXs are widely expressed, although the tissue distribution of each SNX mRNA varies. The ability of SNXs to bind specific phospholipids, as well as their tendency to form protein-protein complexes, suggests a role for these proteins in cellular membrane trafficking and protein sorting. SNXs may also function specifically in pro-degradative sorting, internalization, endosomal recycling or simply in endosomal sorting. SNXs partially associate with cellular membranes, despite their hydrophilic nature. SNX9 resides in the cytosol where it influences the processing and trafficking of insulin receptors. The enzyme aldolase binds to and inactivates SNX9. Phosphorylation of SNX9 releases aldolase and frees SNX9 to recruit and activate Dynamin II, a neuronal phosphoprotein and a GTPase enzyme which mediates late stages of endocytosis in both neural and non-neural cells.
抗原信息
免疫原
KLH conjugated synthetic peptide: human SNX5
抗原种属
Human
基因名称
SNX9
基因ID
51429
蛋白名称
Sorting nexin-9
Uniprot ID
Q9Y5X1
功能
May be involved in several stages of intracellular trafficking. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate.
化学信息
分子量Theoretical: 67 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

  • 稀释 计算器
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