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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-SFRP1 Polyclonal Antibody

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货号 TMAB-12713

Anti-SFRP1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 SFRP1。Anti-SFRP1 Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。

Anti-SFRP1 Polyclonal Antibody

Anti-SFRP1 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-12713

Anti-SFRP1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 SFRP1。Anti-SFRP1 Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍

生物活性
产品描述
Anti-SFRP1 Polyclonal Antibody is a Rabbit antibody targeting SFRP1. Anti-SFRP1 Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Human,Mouse,Rat
应用WBIHC-PIHC-FrIF
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Secreted. Note=Cell membrane or extracellular matrix-associated. Released by heparin-binding.
组织特异性Widely expressed. Absent from lung, liver and peripheral blood leukocytes. Highest levels in heart and fetal kidney. Also expressed in testis, ovary, fetal brain and lung, leiomyomal cells, myometrial cells and vascular smooth muscle cells. Expressed in foreskin fibroblasts and in keratinocytes.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq, Sep 2009]
抗原信息
免疫原
KLH conjugated synthetic peptide: human SFRP1
抗原种属
Human
基因名称
SFRP1
基因ID
6422
蛋白名称
Secreted frizzled-related protein 1
Uniprot ID
Q8N474
功能
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription.
化学信息
分子量Theoretical: 33 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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