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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Seladin 1 Polyclonal Antibody

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货号 TMAB-12635

Anti-Seladin 1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Seladin 1。Anti-Seladin 1 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-Seladin 1 Polyclonal Antibody

Anti-Seladin 1 Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-12635

Anti-Seladin 1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Seladin 1。Anti-Seladin 1 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍

生物活性
产品描述
Anti-Seladin 1 Polyclonal Antibody is a Rabbit antibody targeting Seladin 1. Anti-Seladin 1 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Rat (predicted:Human,Mouse,Dog,Pig,Cow,Horse,Rabbit)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein.
组织特异性Highly expressed in brain and adrenal gland with moderate expression in liver, lung, spleen, prostate and spinal cord. Low expression in heart, uterus and prostate. Undetectable in blood cells. In the brain, strongly expressed in cortical regions, substantia nigra, caudate nucleus, hippocampus, medulla oblongata and pons. In brains affected by Alzheimer disease, expression in the inferior temporal lobe is substantially lower than in the frontal cortex.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Seladin 1 is highly expressed in brain, adrenal tissues and adrenal tumours, where this enzyme catalyzes the reduction of the delta-24 double bond of sterol intermediates such as desmosterol, during cholesterol biosynthesis. In addition, Seladin 1 has an anti-apoptotic function by reducing caspase 3 activity during oxidative stress-induced apoptosis and protecting cells against amyloid-beta peptide-induced apoptosis. Several studies have identified a reduction in expression levels of this enzyme in brain regions affected by Alzheimer's disease (hippocampus and the subventricular zone).
抗原信息
免疫原
KLH conjugated synthetic peptide: human Seladin 1
抗原种属
Human
基因名称
DHCR24
基因ID
1718
蛋白名称
delta(24)-sterol reductase
Uniprot ID
Q15392
化学信息
分子量Theoretical: 55 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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