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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Sclerostin Polyclonal Antibody

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货号 TMAB-12579

Anti-Sclerostin Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Sclerostin。Anti-Sclerostin Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。

Anti-Sclerostin Polyclonal Antibody

Anti-Sclerostin Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-12579

Anti-Sclerostin Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Sclerostin。Anti-Sclerostin Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

生物活性
产品描述
Anti-Sclerostin Polyclonal Antibody is a Rabbit antibody targeting Sclerostin. Anti-Sclerostin Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Human,Mouse,Rat (predicted:Dog,Pig,Cow,Horse,Rabbit,Sheep)
应用WBIHC-PIHC-FrIF
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Secreted.
组织特异性Widely expressed at low levels with highest levels in bone, cartilage, kidney, liver, bone marrow and primary osteeoblasts differentiated for 21 days.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Negative regulator of bone growth.Sclerostin (SOST) is a bone morphogenetic protein (BMP) antagonist, leading to the activation of BMP signaling. It negatively regulates the formation of bone by repressing the differentiation and/or function of osteoblasts induced by BMPs. It has been shown that Sclerostin binds BMP-5, -6, and -7 with high affinity and BMP-2 and -4 with low affinity. The noggin-sclerostin protein complex represents a novel mechanism for the fine-tuning of BMP activity in bone homeostasis. Evidence is accumulating that one of the important mechanisms of bone regulation by sclerostin is the modulation of Wnt/Beta-catenin signaling. Sclerostin also rapidly activated ERK-1/2 MAPK signaling, indicating the involvement of additional signaling pathways
抗原信息
免疫原
KLH conjugated synthetic peptide: human Sclerostin
抗原种属
Human
基因名称
SOST
基因ID
50964
蛋白名称
Sclerostin
Uniprot ID
Q9BQB4
功能
Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.
化学信息
分子量Theoretical: 21 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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