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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-SCARB1/Scavenger Receptor BI Antibody (8A412)

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货号 TMAB-12560

Anti-SCARB1/Scavenger Receptor BI Antibody (8A412) 是一种 Rabbit 抗体，靶向 SCARB1/Scavenger Receptor BI。Anti-SCARB1/Scavenger Receptor BI Antibody (8A412) 可用于 WB,IHC-P,IHC-Fr,ICC/IF,IF。

Anti-SCARB1/Scavenger Receptor BI Antibody (8A412)

Anti-SCARB1/Scavenger Receptor BI Antibody (8A412)

一键复制产品信息
Rating icon 还可以
货号 TMAB-12560

Anti-SCARB1/Scavenger Receptor BI Antibody (8A412) 是一种 Rabbit 抗体，靶向 SCARB1/Scavenger Receptor BI。Anti-SCARB1/Scavenger Receptor BI Antibody (8A412) 可用于 WB,IHC-P,IHC-Fr,ICC/IF,IF。

规格价格库存数量
25 μL
¥ 785
5日内发货
50 μL
¥ 1,395
5日内发货
100 μL
¥ 2,480
5日内发货
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产品介绍

生物活性
产品描述
Anti-SCARB1/Scavenger Receptor BI Antibody (8A412) is a Rabbit antibody targeting SCARB1/Scavenger Receptor BI. Anti-SCARB1/Scavenger Receptor BI Antibody (8A412) can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF.
Ig Type
IgG
克隆号
8A412
反应种属
Human,Mouse,Rat
应用WBIHC-PIHC-FrICC/IFIF
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:200-500; ICC/IF: 1:50-200; IF: 1:100-500
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Cell membrane; Multi-pass membrane protein. Membrane, caveola; Multi-pass membrane protein. Note=Predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called caveolae.
组织特异性Widely expressed. The six cysteines of the extracellular domain are all involved in intramolecular disulfide bonds.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. The SR-BI (Scavenger Receptor BI) protein binds HDLs and mediates selective uptake of HDL cholesteryl ester. SR-BI binds HDL with high affinity, is expressed primarily in liver and nonplacental steroidgenic tissues, and mediates selective cholesterol uptake by a distinct mechanism. In mice, it seems that SR-BI plays a key role in determining the levels of plasma lipoprotein cholesterol and the accumulation of cholesterol stores in the adrenal gland. Scavenging Receptor SR-BI plays a critical role in HCV attachment and/or cell entry by interacting with HCV E1/E2 glycoproteins heterodimer.
抗原信息
免疫原
KLH conjugated synthetic peptide: human SCARB1/Scavenger Receptor BI
抗原种属
Human
基因名称
SCARB1
基因ID
949
蛋白名称
Scavenger receptor class B member 1
Uniprot ID
Q14108
功能
Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for hepatitis C virus glycoprotein E2. Binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. Plays an important role in the uptake of HDL cholesteryl ester.
化学信息
分子量Theoretical: 61 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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