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Anti-S1P/Subtilisin isozyme 1 Polyclonal Antibody

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货号 TMAB-12465

Anti-S1P/Subtilisin isozyme 1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 S1P/Subtilisin isozyme 1。Anti-S1P/Subtilisin isozyme 1 Polyclonal Antibody 可用于 WB。

Anti-S1P/Subtilisin isozyme 1 Polyclonal Antibody

Anti-S1P/Subtilisin isozyme 1 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-12465

Anti-S1P/Subtilisin isozyme 1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 S1P/Subtilisin isozyme 1。Anti-S1P/Subtilisin isozyme 1 Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,165
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100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

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产品描述
Anti-S1P/Subtilisin isozyme 1 Polyclonal Antibody is a Rabbit antibody targeting S1P/Subtilisin isozyme 1. Anti-S1P/Subtilisin isozyme 1 Polyclonal Antibody can be used in WB.
Ig Type
IgG
反应种属
Mouse (predicted:Human,Rat,Chicken,Rabbit)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein.
组织特异性Widely expressed.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the cis/medial-Golgi where a second autocatalytic event takes place and the catalytic activity is acquired. It encodes a type 1 membrane bound protease which is ubiquitously expressed and regulates cholesterol or lipid homeostasis via cleavage of substrates at non-basic residues. Mutations in this gene may be associated with lysosomal dysfunction. [provided by RefSeq, Feb 2014]
抗原信息
免疫原
KLH conjugated synthetic peptide: human S1P/Subtilisin isozyme 1
抗原种属
Human
基因名称
MBTPS1
基因ID
8720
蛋白名称
Membrane-bound transcription factor site-1 protease
Uniprot ID
Q14703
功能
Serine protease that catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF, GNPTAB and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg-Ser-Val-Leu (SERBP-2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lysosomes.
化学信息
分子量Theoretical: 96 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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