购物车
- 全部删除
您的购物车当前为空
Anti-S100B Antibody (5N295)
还可以产品编号 TMAY-00177
Anti-S100B Antibody (5N295) 是一种 Mouse 抗体，靶向 S100B。Anti-S100B Antibody (5N295) 可用于 IHC-P。
Anti-S100B Antibody (5N295)
Anti-S100B Antibody (5N295)
还可以产品编号 TMAY-00177
Anti-S100B Antibody (5N295) 是一种 Mouse 抗体，靶向 S100B。Anti-S100B Antibody (5N295) 可用于 IHC-P。
产品信息正在更新中，如果您想购买，请点击大包装&定制按钮.
大包装 & 定制
联系我们获取更多批次信息
资源下载
产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-S100B Antibody (5N295) is a Mouse antibody targeting S100B. Anti-S100B Antibody (5N295) can be used in IHC-P. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 5N295 |
| 交叉反应 | Human |
| 验证活性 | 1. Immunochemical staining of human S100B in human malignant melanoma with mouse monoclonal antibody at 1:2000 dilution, formalin-fixed paraffin embedded sections. 2. Immunochemical staining of human S100B in human lymphoma with mouse monoclonal antibody at 1:2000 dilution, formalin-fixed paraffin embedded sections. 3. Immunochemical staining of human S100B in human cerebellum with mouse monoclonal antibody at 1:2000 dilution, formalin-fixed paraffin embedded sections. |
| 应用 | IHC-P |
| 推荐剂量 | IHC-P: 1:500-1:3000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with a synthetic peptide corresponding to the N-terminus of the Human S100B . The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | S100B is a member of the S100 family of proteins containing two EF-hand-type calcium-binding motifs. S100B exerts both intracellular and extracellular functions. Intracellular S100B acts as a stimulator of cell proliferation and migration and an inhibitor of apoptosis and differentiation, which might have important implications during brain, cartilage and skeletal muscle development and repair, activation of astrocytes in the course of brain damage and neurodegenerative processes, and of cardiomyocyte remodeling after infarction, as well as in melanomagenesis and gliomagenesis. As an extracellular factor, S100B engages RAGE (receptor for advanced glycation end products) in a variety of cell types with different outcomes (i.e. beneficial or detrimental, pro-proliferative or pro-differentiative) depending on the concentration attained by the protein, the cell type and the microenvironment. This calcium binding astrocyte-specific cytokine, presents a marker of astrocytic activation and reflects CNS injury. The excellent sensitivity of S100B has enabled it to confirm the existence of subtle brain injury in patients with mild head trauma, strokes, and after successful resuscitation from cardiopulmonary arrest. Recent findings provide evidence, that S100B may decrease neuronal injury and/or contribute to repair following traumatic brain injury (TBI). Hence, S100B, far from being a negative determinant of outcome, as suggested previously in the human TBI and ischemia literature, is of potential therapeutic value that could improve outcome in patients who sustain various forms of acute brain damage. |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide corresponding to the N-terminus of the Human S100B |
| 抗原种属 | Human |
| 研究领域 | Calcium-binding Proteins and Related Molecules |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
SCI 文献
计算器
比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
评论列表
预览
Related Tags: buy Anti-S100B Antibody (5N295) | purchase Anti-S100B Antibody (5N295) | Anti-S100B Antibody (5N295) cost | order Anti-S100B Antibody (5N295)
嗨！有任何问题？点我咨询
评论内容