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顶部生物活性储存和溶解信息计算器

Anti-S100B Antibody (1N204)

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Anti-S100B Antibody (1N204)
产品编号 TMAY-00416
别名 S100 calcium binding protein B, Bpb, AI850290

Anti-S100B Antibody (1N204) 是一种 Rabbit 抗体，靶向 S100B。Anti-S100B Antibody (1N204) 可用于 ELISA,IHC-P,ICC/IF。

Anti-S100B Antibody (1N204)
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Anti-S100B Antibody (1N204)

Rating icon 还可以
Anti-S100B Antibody (1N204)
产品编号 TMAY-00416 别名 S100 calcium binding protein B, Bpb, AI850290

Anti-S100B Antibody (1N204) 是一种 Rabbit 抗体，靶向 S100B。Anti-S100B Antibody (1N204) 可用于 ELISA,IHC-P,ICC/IF。

规格价格库存数量
100 μL
¥ 2,294
5日内发货
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产品介绍

生物活性
产品描述
Anti-S100B Antibody (1N204) is a Rabbit antibody targeting S100B. Anti-S100B Antibody (1N204) can be used in ELISA,IHC-P,ICC/IF.
别名S100 calcium binding protein B, Bpb, AI850290
Ig Type
Rabbit IgG
克隆号
1N204
交叉反应
Human
验证活性
1. Immunochemical staining of human S100B in human malignant melanoma with rabbit monoclonal antibody at 1:10000 dilution, formalin-fixed paraffin embedded sections.
2. Immunochemical staining of human S100B in human lymphoma with rabbit monoclonal antibody at 1:10000 dilution, formalin-fixed paraffin embedded sections.
3. Immunofluorescence staining of S100B in U2OS cells. Cells were fixed with 4% PFA, permeabilzed with 0.1% Triton X-100 in PBS,blocked with 10% serum, and incubated with rabbit anti-Human S100B monoclonal antibody (dilution ratio 1:60) at 4°C overnight. Then cells were stained with the Alexa Fluor®488-conjugated Goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI (blue).Positive staining was localized to Cytoplasm.
应用
ELISA,IHC-P,ICC/IF
推荐剂量
ELISA: 1:5000-1:10000; IHC-P: 1:1000-1:10000; ICC-IF: 1:20-1:100
抗体种类
Monoclonal
宿主来源Rabbit
构建方式This antibody was obtained from a rabbit immunized with purified, recombinant Human S100B (rh S100B; TMPY-02531; NP_006263.1; Ser2-Glu92).
纯化方式Protein A
性状Liquid
缓冲液0.2 μm filtered solution in PBS
研究背景S100B is a member of the S100 family of proteins containing two EF-hand-type calcium-binding motifs. S100B exerts both intracellular and extracellular functions. Intracellular S100B acts as a stimulator of cell proliferation and migration and an inhibitor of apoptosis and differentiation, which might have important implications during brain, cartilage and skeletal muscle development and repair, activation of astrocytes in the course of brain damage and neurodegenerative processes, and of cardiomyocyte remodeling after infarction, as well as in melanomagenesis and gliomagenesis. As an extracellular factor, S100B engages RAGE (receptor for advanced glycation end products) in a variety of cell types with different outcomes (i.e. beneficial or detrimental, pro-proliferative or pro-differentiative) depending on the concentration attained by the protein, the cell type and the microenvironment. This calcium binding astrocyte-specific cytokine, presents a marker of astrocytic activation and reflects CNS injury. The excellent sensitivity of S100B has enabled it to confirm the existence of subtle brain injury in patients with mild head trauma, strokes, and after successful resuscitation from cardiopulmonary arrest. Recent findings provide evidence, that S100B may decrease neuronal injury and/or contribute to repair following traumatic brain injury (TBI). Hence, S100B, far from being a negative determinant of outcome, as suggested previously in the human TBI and ischemia literature, is of potential therapeutic value that could improve outcome in patients who sustain various forms of acute brain damage.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein: Human S100B Protein (TMPY-02531)
抗原种属
Human
研究领域
Calcium-binding Proteins and Related Molecules
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.

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AI-850290AI 850290

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