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Anti-RUVBL1 Antibody (3V175)

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货号 TMAB-12434

Anti-RUVBL1 Antibody (3V175) 是一种 Rabbit 抗体，靶向 RUVBL1。Anti-RUVBL1 Antibody (3V175) 可用于 WB,FCM。

Anti-RUVBL1 Antibody (3V175)

Anti-RUVBL1 Antibody (3V175)

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Rating icon 还可以
货号 TMAB-12434

Anti-RUVBL1 Antibody (3V175) 是一种 Rabbit 抗体，靶向 RUVBL1。Anti-RUVBL1 Antibody (3V175) 可用于 WB,FCM。

规格价格库存数量
25 μL
¥ 795
5日内发货
50 μL
¥ 1,390
5日内发货
100 μL
¥ 2,490
5日内发货
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产品介绍

生物活性
产品描述
Anti-RUVBL1 Antibody (3V175) is a Rabbit antibody targeting RUVBL1. Anti-RUVBL1 Antibody (3V175) can be used in WB,FCM.
Ig Type
IgG
克隆号
3V175
反应种属
Human,Mouse,Rat
应用WBFCM
推荐剂量
WB: 1:1000-2000; FCM: 1:50-100
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Nucleus matrix. Nucleus > nucleoplasm. Cytoplasm. Membrane. Cytoplasm > cytoskeleton > centrosome. Mainly localized in the nucleus, associated with nuclear matrix or in the nuclear cytosol, although it is also present in the cytoplasm and associated with the cell membranes. In prophase and prometaphase it is located at the centrosome and the branching microtubule spindles. After mitotic nuclear membrane disintigration it accumulates at the centrosome and sites of tubulin polymerization. As cells pass through metaphase and into telophase it is located close to the centrosome at the early phase of tubulin polymerization. In anaphase it accumulates at the zone of tubule interdigitation. In telophase it is found at polar tubule overlap, and it reappears at the site of chromosomal decondensation in the daughter cells.
组织特异性Ubiquitously expressed with high expression in heart, skeletal muscle and testis.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究背景Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity.Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A.
抗原信息
免疫原
A synthesized peptide: human RUVBL1
抗原种属
Human
基因名称
RUVBL1
基因ID
8607
蛋白名称
RuvB-like 1
Uniprot ID
Q9Y265
功能
Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. RUVBL1 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex.
May be able to bind plasminogen at cell surface and enhance plasminogen activation.
Essential for cell proliferation.
化学信息
分子量Theoretical: 50 kDa. Actual: 50 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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