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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-RPE65 Polyclonal Antibody

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货号 TMAB-12351

Anti-RPE65 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 RPE65。Anti-RPE65 Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。

Anti-RPE65 Polyclonal Antibody

Anti-RPE65 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-12351

Anti-RPE65 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 RPE65。Anti-RPE65 Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,970
5日内发货
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产品介绍

生物活性
产品描述
Anti-RPE65 Polyclonal Antibody is a Rabbit antibody targeting RPE65. Anti-RPE65 Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Mouse
应用WBIHC-PIHC-FrIF
推荐剂量
WB: 1:500-2000; IHC-P: 1:1000-4000; IHC-Fr: 1:400-800; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Cell membrane. Attached to the membrane by a lipid anchor when palmitoylated (membrane form), soluble when unpalmitoylated.
组织特异性Retinal pigment epithelium specific.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The retinal pigment epithelium (RPE) is a monolayer simple epithelium in proximity to the outer surface of the retinal photoreceptor cells. Retinal pigment epithelium-specific protein (RPE65) is a 65 kDa protein belonging to the β-carotene dioxygenase family. This protein is important in 11-cis retinal production as well as in visual pigment regeneration. RPE65 is attached to the membrane by a lipid anchor when palmitoylated (membrane form) and soluble when unpalmitoylated. The soluble form of the protein binds vitamin A. Defects in RPE65 causes autosomal dominant retinitis pigmentosa and/or Leber congenital amaurosis type 2.
抗原信息
免疫原
KLH conjugated synthetic peptide: mouse RPE65
抗原种属
Mouse
基因名称
RPE65
基因ID
19892
蛋白名称
Retinoid isomerohydrolase
Uniprot ID
Q91ZQ5
功能
Plays important roles in the production of 11-cis retinal and in visual pigment regeneration. The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT. The enzymatic activity is linearly dependent of the expression levels and membrane association.
化学信息
分子量Theoretical: 59 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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