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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-RPA70 Polyclonal Antibody

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货号 TMAB-12349

Anti-RPA70 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 RPA70。Anti-RPA70 Polyclonal Antibody 可用于 FCM。

Anti-RPA70 Polyclonal Antibody

Anti-RPA70 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-12349

Anti-RPA70 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 RPA70。Anti-RPA70 Polyclonal Antibody 可用于 FCM。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

生物活性
产品描述
Anti-RPA70 Polyclonal Antibody is a Rabbit antibody targeting RPA70. Anti-RPA70 Polyclonal Antibody can be used in FCM.
Ig Type
IgG
反应种属
Human (predicted:Mouse,Rat,Dog,Pig,Rabbit)
应用FCM
推荐剂量
FCM: 1μg/Test
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The single-stranded-DNA-binding proteins (SSBs) are essential for DNA function in prokaryotic and eukaryotic cells, mitochondria, phages and viruses. Replication protein A (RPA), a highly conserved eukaryotic protein, is a heterotrimeric SSB. RPA plays an important role in DNA replication, recombination and repair. The binding of human RPA (hRPA) to DNA involves molecular polarity in which initial hRPA binding occurs on the 5' side of an ssDNA substrate and then extends in the 3' direction to create a stably bound hRPA. RPA is a major damage-recognition protein involved in the early stages of nucleotide excision repair. It can also play a role in telomere maintenance. The RPA 70 kDa subunit binds to ssDNA and mediates interactions with many cellular and viral proteins. The DNA binding domain lies in the middle of RPA 70 kDa subunit and comprises two structurally homologous subdomains oriented in tandem. RPA contains a conserved four cysteine-type zinc-finger motif, which mediates the transition of RPA-ssDNA interaction to a stable RPA-ssDNA complex in a redox-dependent manner.
抗原信息
免疫原
KLH conjugated synthetic peptide: human RPA70
抗原种属
Human
基因名称
RPA1
基因ID
6117
蛋白名称
Replication protein A 70 kDa DNA-binding subunit
Uniprot ID
P27694
功能
Plays an essential role in several cellular processes in DNA metabolism including replication, recombination and DNA repair. Binds and subsequently stabilizes single-stranded DNA intermediates and thus prevents complementary DNA from reannealing.
化学信息
分子量Theoretical: 68 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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