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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-RNF216 Polyclonal Antibody

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货号 TMAB-12315

Anti-RNF216 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 RNF216。Anti-RNF216 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-RNF216 Polyclonal Antibody

Anti-RNF216 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-12315

Anti-RNF216 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 RNF216。Anti-RNF216 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍

生物活性
产品描述
Anti-RNF216 Polyclonal Antibody is a Rabbit antibody targeting RNF216. Anti-RNF216 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Human (predicted:Mouse,Rat,Dog,Horse)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasmic
组织特异性Ubiquitous, with the highest levels of expression in testis and peripheral blood leukocytes.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The TRIAD3 gene encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes and transfers it to substrates. Several alternatively spliced transcript variants have been described for this locus but the full-length natures of only some are known.
抗原信息
免疫原
KLH conjugated synthetic peptide: human TRIAD3
抗原种属
Human
基因名称
RNF216
基因ID
54476
蛋白名称
E3 ubiquitin-protein ligase RNF216
Uniprot ID
Q9NWF9
功能
Isoform 1 acts as an E3 ubiquitin ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Promotes degradation of TRAF3, TLR4 and TLR9. Contributes to the regulation of antiviral responses. Down-regulates activation of NF-kappa-B, IRF3 activation and IFNB production. Isoform 3/ZIN inhibits TNF and IL-1 mediated activation of NF-kappa-B. Promotes TNF and RIP mediated apoptosis.
化学信息
分子量Theoretical: 99 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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