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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-RNF213 Polyclonal Antibody

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货号 TMAB-12314

Anti-RNF213 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 RNF213。Anti-RNF213 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-RNF213 Polyclonal Antibody

Anti-RNF213 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-12314

Anti-RNF213 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 RNF213。Anti-RNF213 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-RNF213 Polyclonal Antibody is a Rabbit antibody targeting RNF213. Anti-RNF213 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Mouse,Rat (predicted:Human,Pig,Cow,Horse,Sheep)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm.
组织特异性Widely expressed (at protein level).
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made up of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. RNF213 (ring finger protein 213), also known as NET57, is a 3,280 amino acid protein containing one RING-type zinc finger domain through which it may play a role in transcriptional regulation and protein degradation. RNF213 is encoded by a gene located on human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.
抗原信息
免疫原
KLH conjugated synthetic peptide: human RNF213
抗原种属
Human
基因名称
RNF213
基因ID
57674
蛋白名称
E3 ubiquitin-protein ligase RNF213
Uniprot ID
Q9HCF4
功能
Probable E3 ubiquitin-protein ligase that may play a role in angiogenesis. May also have an ATPase activity.
化学信息
分子量Theoretical: 591 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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