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Anti-RNF20 Antibody (4H387) 是一种 Rabbit 抗体,靶向 RNF20。Anti-RNF20 Antibody (4H387) 可用于 WB,ICC/IF,IP,FCM。
Anti-RNF20 Antibody (4H387) 是一种 Rabbit 抗体,靶向 RNF20。Anti-RNF20 Antibody (4H387) 可用于 WB,ICC/IF,IP,FCM。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 25 μL | ¥ 780 | 5日内发货 | |
| 50 μL | ¥ 1,390 | 5日内发货 | |
| 100 μL | ¥ 2,485 | 5日内发货 |
| 产品描述 | Anti-RNF20 Antibody (4H387) is a Rabbit antibody targeting RNF20. Anti-RNF20 Antibody (4H387) can be used in WB,ICC/IF,IP,FCM. |
| Ig Type | IgG |
| 克隆号 | 4H387 |
| 反应种属 | Human (predicted:Mouse) |
| 应用 | WBICC/IFIPFCM |
| 推荐剂量 | WB: 1:1000-2000; ICC/IF: 1:50-200; IP: 1:20-50; FCM: 1:50-100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Nuclear |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Protein A purified |
| 性状 | Liquid |
| 缓冲液 | 10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| 研究背景 | Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role inb histone code and gene regulation. |
| 免疫原 | A synthesized peptide: human RNF20 |
| 抗原种属 | Human |
| 基因名称 | RNF20 |
| 基因ID | |
| 蛋白名称 | E3 ubiquitin-protein ligase BRE1A |
| Uniprot ID | |
| 功能 | Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. |
| 分子量 | Theoretical: 114 kDa. Actual: 114 kDa. |
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
| 存储 | store at low temperature | -20°C for 1 year |