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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-RNF111 Polyclonal Antibody

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货号 TMAB-12282

Anti-RNF111 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 RNF111。Anti-RNF111 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-RNF111 Polyclonal Antibody

Anti-RNF111 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-12282

Anti-RNF111 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 RNF111。Anti-RNF111 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍

生物活性
产品描述
Anti-RNF111 Polyclonal Antibody is a Rabbit antibody targeting RNF111. Anti-RNF111 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Mouse,Rat (predicted:Human,Dog,Cow,Rabbit,Sheep)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasmic and Nuclear
组织特异性Broadly expressed.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]
抗原信息
免疫原
KLH conjugated synthetic peptide: human RNF111
抗原种属
Human
基因名称
RNF111
基因ID
54778
蛋白名称
E3 ubiquitin-protein ligase Arkadia
Uniprot ID
Q6ZNA4
功能
Acts in the NODAL pathway of mesoderm patterning during embryonic development. Acts downstream AXIN1 as an E3 ubiquitin-protein ligase which promotes the ubiquitination of inhibitory SMADs such as SMAD7, induces their proteasomal degradation and thereby enhances the transcriptional activity of TGF-beta and BMP. Activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation.
化学信息
分子量Theoretical: 109 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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