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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-RING2 Antibody (1U338)

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货号 TMAB-12263

Anti-RING2 Antibody (1U338) 是一种 Rabbit 抗体，靶向 RING2。Anti-RING2 Antibody (1U338) 可用于 WB,IHC-P,IHC-Fr,ICC/IF,IF,FCM。

Anti-RING2 Antibody (1U338)

Anti-RING2 Antibody (1U338)

一键复制产品信息
Rating icon 还可以
货号 TMAB-12263

Anti-RING2 Antibody (1U338) 是一种 Rabbit 抗体，靶向 RING2。Anti-RING2 Antibody (1U338) 可用于 WB,IHC-P,IHC-Fr,ICC/IF,IF,FCM。

规格价格库存数量
25 μL
¥ 780
5日内发货
50 μL
¥ 1,390
5日内发货
100 μL
¥ 2,480
5日内发货
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产品介绍

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产品描述
Anti-RING2 Antibody (1U338) is a Rabbit antibody targeting RING2. Anti-RING2 Antibody (1U338) can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF,FCM.
Ig Type
IgG
克隆号
1U338
反应种属
Human,Mouse,Rat
应用WBIHC-PIHC-FrICC/IFIFFCM
推荐剂量
WB: 1:1000-2000; IHC-P: 1:100-200; IHC-Fr: 1:100-200; ICC/IF: 1:50-200; IF: 1:50-200; FCM: 1:50-100
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Nucleus. Chromosome. Note=Enriched on inactive X chromosome (Xi) in female trophoblast stem (TS) cells as well as differentiating embryonic stem (ES) cells. The enrichment on Xi is transient during TS and ES cell differentiation. The association with Xi is mitotically stable in non-differentiated TS cells.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究背景Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity (Probable). Association with the chromosomal DNA is cell-cycle dependent. In resting B- and T-lymphocytes, interaction with AURKB leads to block its activity, thereby maintaining transcription in resting lymphocytes.Also acts as a negative regulator of autophagy by mediating ubiquitination of AMBRA1, leading to its subsequent degradation.
抗原信息
免疫原
A synthesized peptide: human RING2
抗原种属
Human
基因名称
RNF2
基因ID
6045
蛋白名称
E3 ubiquitin-protein ligase RING2
Uniprot ID
Q99496
功能
E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4. Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity.
化学信息
分子量Theoretical: 38 kDa. Actual: 38 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

  • 稀释 计算器
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