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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Renalase Polyclonal Antibody

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货号 TMAB-12186

Anti-Renalase Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Renalase。Anti-Renalase Polyclonal Antibody 可用于 WB。

Anti-Renalase Polyclonal Antibody

Anti-Renalase Polyclonal Antibody

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货号 TMAB-12186

Anti-Renalase Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Renalase。Anti-Renalase Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

生物活性
产品描述
Anti-Renalase Polyclonal Antibody is a Rabbit antibody targeting Renalase. Anti-Renalase Polyclonal Antibody can be used in WB.
Ig Type
IgG
反应种属
Human,Mouse (predicted:Rat,Dog,Pig,Horse,Rabbit)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Secreted.
组织特异性Secreted into the blood by the kidney. Highly expressed in the kidney, expressed at lower level in heart, skeletal muscle and small intestine. Its plasma concentration is markedly reduced in patients with end-stage renal disease, as compared with healthy subjects.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Renalase, a novel FAD dependent amine oxidase, is secreted by the kidney, degrades circulating catecholamines, and modulates cardiac function and lowers systemic blood pressure. In vivo, it has been found to decrease cardiac contractility and heart rate and prevents a compensatory increase in peripheral vascular tone, possibly explaining the association between increased plasma catecholamines and heightened cardiovascular risk. The plasma concentration of renalase is markedly reduced in patients with end-stage renal disease, as compared with healthy subjects. The administration of renalase (or renalase mimics) may offer a new approach to the treatment of hypertension commonly found in renal disease, which is associated with a marked increase in cardiovascular disease.
抗原信息
免疫原
KLH conjugated synthetic peptide: human Renalase
抗原种属
Human
基因名称
RNLS
基因ID
55328
蛋白名称
Renalase
Uniprot ID
Q5VYX0
功能
Probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood and modulates cardiac function and systemic blood pressure. Degrades catecholamines such as dopamine, norepinephrine and epinephrine in vitro. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis (By similarity). According to PubMed:17385068, is unlikely that renalase has physiologically relevant catecholamine-oxidizing activity.
化学信息
分子量Theoretical: 36 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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