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顶部产品介绍偶联与修饰抗原信息储存和溶解信息计算器

Anti-RELB Monoclonal Antibody (7A700)

Synonyms: REL-B, I-REL, IREL
货号 TMAT-1191 一键复制产品信息
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Anti-RELB Monoclonal Antibody (7A700) 是一种 Mouse 抗体，靶向 RELB。Anti-RELB Monoclonal Antibody (7A700) 可用于 IHC,IF,FCM。

Anti-RELB Monoclonal Antibody (7A700)

一键复制产品信息
Rating icon 还可以
货号 TMAT-1191

别名 REL-B, I-REL, IREL

Anti-RELB Monoclonal Antibody (7A700) 是一种 Mouse 抗体，靶向 RELB。Anti-RELB Monoclonal Antibody (7A700) 可用于 IHC,IF,FCM。

Anti-RELB Monoclonal Antibody (7A700)
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产品介绍

生物活性
产品描述
Anti-RELB Monoclonal Antibody (7A700) is a Mouse antibody targeting RELB. Anti-RELB Monoclonal Antibody (7A700) can be used in IHC,IF,FCM.
别名
REL-B, I-REL, IREL
Ig Type
IgG2a
克隆号
7A700
反应种属
Human
应用IHCIFFCM
推荐剂量
IHC: 1/200-1/1000; IF: 1/200-1/1000; FCM: 1/200-1/400
抗体种类
Monoclonal
宿主来源Mouse
构建方式Hybridoma Monoclonal Antibody
纯化方式Purified by protein A or protein G
性状Liquid
缓冲液PBS with 0.05% sodium azide.
浓度1 mg/mL
研究背景NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Purified recombinant fragment of human RELB (AA: 273-443) expressed in E. Coli.
抗原种属
Human
基因名称
RELB
基因ID
5971
蛋白名称
Transcription factor RelB
Uniprot ID
Q01201
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

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