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顶部产品介绍偶联与修饰抗原信息化学信息储存和溶解信息计算器

Anti-RAN Monoclonal Antibody (9S993)

Synonyms: TC4, Gsp1, ARA24
货号 TMAT-1162 一键复制产品信息
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Anti-RAN Monoclonal Antibody (9S993) 是一种 Mouse 抗体，靶向 RAN。Anti-RAN Monoclonal Antibody (9S993) 可用于 WB,IHC,IF,FCM。

Anti-RAN Monoclonal Antibody (9S993)

一键复制产品信息
Rating icon 还可以
货号 TMAT-1162

别名 TC4, Gsp1, ARA24

Anti-RAN Monoclonal Antibody (9S993) 是一种 Mouse 抗体，靶向 RAN。Anti-RAN Monoclonal Antibody (9S993) 可用于 WB,IHC,IF,FCM。

Anti-RAN Monoclonal Antibody (9S993)
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产品介绍

生物活性
产品描述
Anti-RAN Monoclonal Antibody (9S993) is a Mouse antibody targeting RAN. Anti-RAN Monoclonal Antibody (9S993) can be used in WB,IHC,IF,FCM.
别名
TC4, Gsp1, ARA24
Ig Type
IgG1
克隆号
9S993
反应种属
Human,Mouse,Monkey,Rat
应用WBIHCIFFCM
推荐剂量
WB: 1/500-1/2000; IHC: 1/200-1/1000; IF: 1/200-1/1000; FCM: 1/200-1/400
抗体种类
Monoclonal
宿主来源Mouse
构建方式Hybridoma Monoclonal Antibody
纯化方式Purified by protein A or protein G
性状Liquid
缓冲液PBS with 0.05% sodium azide
浓度1 mg/mL
研究背景RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Purified recombinant fragment of human RAN (AA: 1-216) expressed in E. Coli.
抗原种属
Human
基因名称
RAN
基因ID
5901
蛋白名称
GTP-binding nuclear protein Ran
Uniprot ID
P62826
化学信息
分子量Theoretical: 24.4 kDa.
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

  • 稀释 计算器
  • 配液 计算器
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