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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-RAD21 Antibody (8Y986)

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货号 TMAB-12034

Anti-RAD21 Antibody (8Y986) 是一种 Rabbit 抗体，靶向 RAD21。Anti-RAD21 Antibody (8Y986) 可用于 WB,FCM。

Anti-RAD21 Antibody (8Y986)

Anti-RAD21 Antibody (8Y986)

一键复制产品信息
Rating icon 还可以
货号 TMAB-12034

Anti-RAD21 Antibody (8Y986) 是一种 Rabbit 抗体，靶向 RAD21。Anti-RAD21 Antibody (8Y986) 可用于 WB,FCM。

规格价格库存数量
25 μL
¥ 790
5日内发货
50 μL
¥ 1,380
5日内发货
100 μL
¥ 2,490
5日内发货
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产品介绍

生物活性
产品描述
Anti-RAD21 Antibody (8Y986) is a Rabbit antibody targeting RAD21. Anti-RAD21 Antibody (8Y986) can be used in WB,FCM.
Ig Type
IgG
克隆号
8Y986
反应种属
Human,Mouse,Rat
应用WBFCM
推荐剂量
WB: 1:500-2000; FCM: 1:50-100
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Nucleus. Chromosome. Chromosome, centromere. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, it is cleaved by separase/ESPL1, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. Once cleaved by caspase-3, the C-terminal 64 kDa cleavage product translocates to the cytoplasm, where it may trigger apoptosis.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究背景As a member of the cohesin complex, involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post-replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions.
抗原信息
免疫原
A synthesized peptide: human RAD21
抗原种属
Human
基因名称
RAD21
基因ID
5885
蛋白名称
Double-strand-break repair protein rad21 homolog
Uniprot ID
O60216
功能
Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Also plays a role in apoptosis, via its cleavage by caspase-3/CASP3 or caspase-7/CASP7 during early steps of apoptosis: the C-terminal 64 kDa cleavage product may act as a nuclear signal to initiate cytoplasmic events involved in the apoptotic pathway.
化学信息
分子量Theoretical: 72 kDa. Actual: 128 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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