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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-RAB5B Polyclonal Antibody

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货号 TMAB-12005

Anti-RAB5B Polyclonal Antibody 是一种 Rabbit 抗体，靶向 RAB5B。Anti-RAB5B Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF,ELISA。

Anti-RAB5B Polyclonal Antibody

Anti-RAB5B Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-12005

Anti-RAB5B Polyclonal Antibody 是一种 Rabbit 抗体，靶向 RAB5B。Anti-RAB5B Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF,ELISA。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍

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产品描述
Anti-RAB5B Polyclonal Antibody is a Rabbit antibody targeting RAB5B. Anti-RAB5B Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF,ELISA.
Ig Type
IgG
反应种属
Human,Mouse,Rat
应用IHC-PIHC-FrIFELISA
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; ELISA: 1:5000-10000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cell membrane; Lipid-anchor; Cytoplasmic side. Early endosome membrane; Lipid-anchor. Melanosome. Note=Enriched in stage I melanosomes.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The Ras-related superfamily of guanine nucleotide binding proteins, which includes the R-Ras, Rap, Ral/Rec and Rho/Rab subfamilies, exhibit 30-60% homology with Ras p21. Accumulating data suggests an important role for Rab proteins, either in endocytosis or in biosynthetic protein transport. The transport of newly synthesized proteins from the endoplasmic reticulum to various stacks of the Golgi complex and to secretory vesicles involves at each stage the movement of carrier vesicles, a process that appears to involve Rab protein function. The possibility that Rab proteins might also direct the exocytosis from secretory vesicles to the plasma membrane is supported by the observation that in yeast, the SEC4 protein, which is 40% homologous to Rab proteins, is associated with secretory vesicles. At least eight members of the Rab subfamily have been identified, each of which is found at a particular stage of a membrane transport pathway.
抗原信息
免疫原
KLH conjugated synthetic peptide: human Rab5b
抗原种属
Human
基因名称
RAB5B
基因ID
5869
蛋白名称
Ras-related protein Rab-5B
Uniprot ID
P61020
功能
Rab5b is a member of the Rab family of small (monomeric) G proteins. Like other small G proteins, Rab5b switches between an inactive, GDP-form and an active, GTP-bound form. GDP/GTP exchange factors (GEFs) catalyse the conversion from the GDP-bound form to the GTP-bound form, while GTPase-activating proteins (GAPs) catalyse GTP hydrolysis to GDP. Rab5b is involved in endocytosis and recycling of cell surface molecules. It interacts with RIN2 and RIN3, which regulate its function, possibly by acting as GEFs. Knockdown of Rab5b abolished group I metabotropic glutamate receptor (mGluR)-mediated neuroprotection. Furthermore, Rab5b interacts with LRRK2, the defective gene at the PARK8 locus that results in Parkinson's disease. Roles for Rab5b in neurodegenerative disease, neuroprotection, and synaptic plasticity have been suggested.
化学信息
分子量Theoretical: 24 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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