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Anti-RAB3GAP1 Antibody (7T374)

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货号 TMAB-11996

Anti-RAB3GAP1 Antibody (7T374) 是一种 Mouse 抗体，靶向 RAB3GAP1。Anti-RAB3GAP1 Antibody (7T374) 可用于 WB,ICC/IF。

Anti-RAB3GAP1 Antibody (7T374)

Anti-RAB3GAP1 Antibody (7T374)

一键复制产品信息
Rating icon 还可以
货号 TMAB-11996

Anti-RAB3GAP1 Antibody (7T374) 是一种 Mouse 抗体，靶向 RAB3GAP1。Anti-RAB3GAP1 Antibody (7T374) 可用于 WB,ICC/IF。

规格价格库存数量
25 μL
¥ 780
5日内发货
50 μL
¥ 1,390
5日内发货
100 μL
¥ 2,485
5日内发货
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产品介绍

生物活性
产品描述
Anti-RAB3GAP1 Antibody (7T374) is a Mouse antibody targeting RAB3GAP1. Anti-RAB3GAP1 Antibody (7T374) can be used in WB,ICC/IF.
Ig Type
IgG1, Kappa
克隆号
7T374
反应种属
Human (predicted:Mouse)
应用WBICC/IF
推荐剂量
WB: 1:500-1000; ICC/IF: 1:100-500
抗体种类
Monoclonal
宿主来源Mouse
亚细胞定位Cytoplasm. Note=In neurons, it is enriched in the synaptic soluble fraction.
组织特异性Ubiquitous.
构建方式Recombinant Antibody
纯化方式Protein G purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab 3 GAP p130, also known as Rab3 GTPase-activating protein catalytic subunit, is a 981 amino acid protein that belongs to the Rab3-GAP catalytic subunit family. Rab 3 GAP p130 converts active RAB3-GTP to the inactive form RAB3-GDP, and is required for normal eye and brain development. Defects in Rab 3 GAP p130 are the cause of Warburg micro syndrome 1 (WARBM1). WARBM1 is a severe autosomal recessive disorder characterized by developmental abnormalities of the eye and central nervous system and by microgenitalia. The Rab 3 GAP p130 protein may participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters. Existing as two alternatively spliced isoforms, the Rab 3 GAP p130 gene is conserved in chimpanzee, dog, cow, mouse, chicken, zebrafish and fruit fly, and maps to human chromosome 2q21.3.
抗原信息
基因名称
RAB3GAP1
基因ID
22930
蛋白名称
Rab3 GTPase-activating protein catalytic subunit
功能
RAB3GAP1 is a member of the RAB3 protein family which are implicated in regulated exocytosis of neurotransmitters and hormones. RAB3GAP, which is involved in regulation of RAB3 activity, is a heterodimeric complex consisting a 130-kD catalytic subunit and a 150-kD noncatalytic subunit. RAB3GAP specifically converts active RAB3-GTP to the inactive form RAB3-GDP (Aligianis et al., 2005 [PubMed 15696165].
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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