Anti-R-Spondin 2/RSPO2 Polyclonal Antibody is a Rabbit antibody targeting R-Spondin 2/RSPO2. Anti-R-Spondin 2/RSPO2 Polyclonal Antibody can be used in WB.

IgG

Mouse,Rat (predicted:Human,Dog,Pig,Cow)

Sample:
Lane 1: Mouse Cerebrum tissue lysates
Lane 2: Mouse Large intestine tissue lysates
Lane 3: Mouse Placenta tissue lysates
Lane 4: Mouse Liver tissue lysates
Lane 5: Mouse Lung tissue lysates
Lane 6: Rat Cerebrum tissue lysates
Lane 7: Rat Large intestine tissue lysates
Lane 8: Rat Placenta tissue lysates
Lane 9: Rat Liver tissue lysates
Lane 10: Rat Lung tissue lysates
Primary: Anti-RSPO2 (TMAB-01637) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 26 kDa
Observed band size: 28 kDa

WB: 1:500-2000

Polyclonal

KLH conjugated synthetic peptide: human RSPO2

Human

RSPO2

R-spondin-2

Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a ligand for frizzled and LRP receptors.