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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-QPRTase Polyclonal Antibody

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货号 TMAB-01599

别名 Quinolinate Phosphoribosyltransferase [Decarboxylating], QPRTase, QPRT, QAPRTase, Nicotinate-Nucleotide Pyrophosphorylase [Carboxylating]

Anti-QPRTase Polyclonal Antibody 是一种 Rabbit 抗体，靶向 QPRTase。Anti-QPRTase Polyclonal Antibody 可用于 IF,IHC-Fr,IHC-P,WB。

Anti-QPRTase Polyclonal Antibody

Anti-QPRTase Polyclonal Antibody

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货号 TMAB-01599 别名 Quinolinate Phosphoribosyltransferase [Decarboxylating], QPRTase, QPRT, QAPRTase, Nicotinate-Nucleotide Pyrophosphorylase [Carboxylating]

Anti-QPRTase Polyclonal Antibody 是一种 Rabbit 抗体，靶向 QPRTase。Anti-QPRTase Polyclonal Antibody 可用于 IF,IHC-Fr,IHC-P,WB。

规格价格库存数量
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

生物活性
产品描述
Anti-QPRTase Polyclonal Antibody is a Rabbit antibody targeting QPRTase. Anti-QPRTase Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P,WB.
别名Quinolinate Phosphoribosyltransferase [Decarboxylating], QPRTase, QPRT, QAPRTase, Nicotinate-Nucleotide Pyrophosphorylase [Carboxylating]
Ig Type
IgG
反应种属
Mouse,Rat (predicted:Human,Dog,Cow,Sheep)
验证活性
1. Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 min; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (Quinolinate phosphoribosyltransferase; QPRT/QAPRTase) Polyclonal Antibody, Unconjugated (TMAB-01599) at 1:400 overnight at 4°C, followed by a conjugated secondary for 20 min and DAB staining.
2. Sample: Liver (mouse) Lysate at 40 μg
Primary: Anti-QPRT/QAPRTase (TMAB-01599) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 31 kDa
Observed band size: 31 kDa
3. Sample:
Lane 1: Mouse Liver tissue lysates
Lane 2: Mouse Large intestine tissue lysates
Lane 3: Mouse Kidney tissue lysates
Primary: Anti-QPRT/QAPRTase (TMAB-01599) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 31 kDa
Observed band size: 28 kDa
verifiedActivityverifiedActivityverifiedActivity
应用IFIHC-FrIHC-PWB
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Hexamer formed by 3 homodimers.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液Preservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4.
浓度1 mg/mL
研究背景Quinolinate phosphoribosyltransferase (QPRTase) is a major enzyme in the catabolism of quinolinate. Quinolinate is an intermediate in the tryptophan-nicotinamide adenine dinucleotide (NAD) pathway, leading to the production of nicotinic acid, carbon dioxide, and pyrophosphate. Catabolism of quinolinate is vital due to the quinolinate’s neurotoxicity. Increased levels of quinolinate have been linked to neurodegenerative symptoms associated with meningitis and AIDS. QAPRTase has a seven-stranded alpha/beta-barrel domain which is similar in structure to the eight-stranded alpha/beta-barrel enzymes. The protein possesses a novel fold in comparison to other members of the PRTase family. This fold comprises a structure combining two domains. The structure is part alpha/beta barrel-like domain, and part alpha/beta N-terminal domain.
抗原信息
免疫原
KLH conjugated synthetic peptide: human QPRT/QAPRTase
抗原种属
Human
基因名称
QPRT
基因ID
23475
蛋白名称
Nicotinate-nucleotide pyrophosphorylase [carboxylating]
Uniprot ID
Q15274
研究领域
Amino acid metabolism,Neurodegenerative disease,Alzheimer's disease,Huntington's disease,Neurodegenerative disease,Amino Acids
功能
Involved in the catabolism of quinolinic acid (QA).
化学信息
分子量Theoretical: 31 kDa.
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | store at -20°C

计算器

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