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Anti-PTP1B Antibody (7G428)

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货号 TMAB-11914

Anti-PTP1B Antibody (7G428) 是一种 Rabbit 抗体，靶向 PTP1B。Anti-PTP1B Antibody (7G428) 可用于 WB,IHC-P,IHC-Fr,ICC/IF,IF,FCM。

Anti-PTP1B Antibody (7G428)

Anti-PTP1B Antibody (7G428)

一键复制产品信息
Rating icon 还可以
货号 TMAB-11914

Anti-PTP1B Antibody (7G428) 是一种 Rabbit 抗体，靶向 PTP1B。Anti-PTP1B Antibody (7G428) 可用于 WB,IHC-P,IHC-Fr,ICC/IF,IF,FCM。

规格价格库存数量
25 μL
¥ 780
5日内发货
50 μL
¥ 1,385
5日内发货
100 μL
¥ 2,490
5日内发货
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产品介绍

生物活性
产品描述
Anti-PTP1B Antibody (7G428) is a Rabbit antibody targeting PTP1B. Anti-PTP1B Antibody (7G428) can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF,FCM.
Ig Type
IgG
克隆号
7G428
反应种属
Human,Mouse,Rat
应用WBIHC-PIHC-FrICC/IFIFFCM
推荐剂量
WB: 1:500-2000; IHC-P: 1:200-500; IHC-Fr: 1:200-500; ICC/IF: 1:50-200; IF: 1:200-500; FCM: 1:50-100
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=Interacts with EPHA3 at the cell membrane.
组织特异性Most abundant in testis. Also found in kidney, spleen, muscle, liver, heart and brain.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
抗原信息
免疫原
A synthesized peptide: human PTPN1
抗原种属
Human
基因名称
PTPN1
基因ID
5770
蛋白名称
Tyrosine-protein phosphatase non-receptor type 1
Uniprot ID
P18031
功能
Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion
化学信息
分子量Theoretical: 50 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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