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Anti-PTF1A Polyclonal Antibody 2

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货号 TMAB-11894

Anti-PTF1A Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 PTF1A。Anti-PTF1A Polyclonal Antibody 2 可用于 WB。

Anti-PTF1A Polyclonal Antibody 2

Anti-PTF1A Polyclonal Antibody 2

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Rating icon 还可以
货号 TMAB-11894

Anti-PTF1A Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 PTF1A。Anti-PTF1A Polyclonal Antibody 2 可用于 WB。

规格价格库存数量
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-PTF1A Polyclonal Antibody 2 is a Rabbit antibody targeting PTF1A. Anti-PTF1A Polyclonal Antibody 2 can be used in WB.
Ig Type
IgG
反应种属
Mouse (predicted:Human,Rat,Chicken,Pig,Cow)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus. Cytoplasm. In chronic pancreatitis associated with pancreas cancer preferentially accumulates in the cytoplasm of acinar/ductular complexes. In the cytoplasm loses its ability to form the PTF1 complex.
组织特异性Pancreas-specific (at protein level). Loss of expression is seen in ductal type pancreas cancers.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景PTF1 is a pancreas-specific protein that functions as a component of the trimeric pancreas transcription factor 1 (PTF1) complex. Localizing to the nucleus, PTF1 contains one basic helix-loop-helix (bHLH) domain and is believed to play an important role in mammalian pancreatic development, functioning as a transcription factor that regulates the specification of all three pancreatic cell types. PTF1 interacts with RBP-Jⅹ and, together, they cooperate in regulating the expression of PDX-1 (pancreas/duodenum homeobox protein 1), a key regulator of pancreatic islet development and insulin gene transcription in beta-cells. Loss of functional PTF1 can cause pancreatic progenitors to take on the normal fates of duodenal epithelia. Mutations in the gene encoding PTF1 lead to diabetes mellitus and cerebellar hypoplasia/agenesis, suggesting that PTF1 also plays and important role in cerebellar neurogenesis.
抗原信息
免疫原
KLH conjugated synthetic peptide: human PTF1A
抗原种属
Human
基因名称
PTF1A
基因ID
256297
蛋白名称
Pancreas transcription factor 1 subunit alpha
Uniprot ID
Q7RTS3
功能
Transcriptional activator. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays an important role in determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an important role in cerebellar development.
化学信息
分子量Theoretical: 35 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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