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Anti-PSMA Antibody (6F983)

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产品编号 TMAY-02805

Anti-PSMA Antibody (6F983) 是一种 Mouse 抗体,靶向 PSMA。Anti-PSMA Antibody (6F983) 可用于 ICC/IF。

Anti-PSMA Antibody (6F983)

Anti-PSMA Antibody (6F983)

Rating icon 还可以
产品编号 TMAY-02805

Anti-PSMA Antibody (6F983) 是一种 Mouse 抗体,靶向 PSMA。Anti-PSMA Antibody (6F983) 可用于 ICC/IF。

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产品介绍

生物活性
产品描述
Anti-PSMA Antibody (6F983) is a Mouse antibody targeting PSMA. Anti-PSMA Antibody (6F983) can be used in ICC/IF.
Ig Type
Monoclonal Mouse IgG1
克隆号
6F983
交叉反应
Human
验证活性
Immunofluorescence staining of S1h-3C-FOLH1 in LNCaP cells. Cells were fixed with 4% PFA, permeabilzed with 0.1% Triton X-100 in PBS,blocked with 10% serum, and incubated with mouse anti-Human S1h-3C-FOLH1 monoclonal antibody (dilution ratio 1:60) at 4°C overnight. Then cells were stained with the Alexa Fluor®488-conjugated Goat Anti-mouse IgG secondary antibody (green) and counterstained with DAPI (blue). Positive staining was localized to Cytoplasm and Cell membrane.
应用
ICC/IF
推荐剂量
ICC-IF: 1:20-1:100
抗体种类
Monoclonal
宿主来源Mouse
构建方式This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human PSMA / FOLH1 (rh PSMA / FOLH1; NP_004467.1Lys44-Ala750). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
纯化方式Protein A
性状Liquid
缓冲液0.2 μm filtered solution in PBS
研究背景Glutamate carboxypeptidase 2, also known as Glutamate carboxypeptidase II, Membrane glutamate carboxypeptidase, Prostate-specific membrane antigen, GCPII, PSMA, FOLH1, and NAALAD1, is a single-pass type II membrane protein which belongs to thepeptidase M28 family and M28B subfamily. FOLH1 is highly expressed in prostate epithelium. It is detected in urinary bladder, kidney, testis, ovary, fallopian tube, breast, adrenal gland, liver, esophagus, stomach, small intestine, colon, brain (at protein level), and the capillary endothelium of a variety of tumors. FOLH1 has both folate hydrolase and N-acetylated alpha linked acidic dipeptidase (NAALADase) activity. It has a preference for tri-alpha-glutamate peptides. Genetic variation in FOLH1 may be associated with low folate levels and consequent hyperhomocysteinemia. This condition can result in increased risk of cardiovascular disease, neural tube defects, and cognitive deficits. FOLH1 also shows a promising role in directed imaging and therapy of recurrent or metastatic disease.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Human PSMA / FOLH1 Protein
抗原种属
Human
研究领域
Cancer Drug Targets, Neurotransmitter Associated Enzymes
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.

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