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顶部产品介绍偶联与修饰抗原信息化学信息储存和溶解信息计算器

Anti-PROZ Monoclonal Antibody (8L93)

Synonyms: PZ, protein Z
货号 TMAT-0924 一键复制产品信息
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Anti-PROZ Monoclonal Antibody (8L93) 是一种 Mouse 抗体，靶向 PROZ。Anti-PROZ Monoclonal Antibody (8L93) 可用于 WB。

Anti-PROZ Monoclonal Antibody (8L93)

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货号 TMAT-0924

别名 PZ, protein Z

Anti-PROZ Monoclonal Antibody (8L93) 是一种 Mouse 抗体，靶向 PROZ。Anti-PROZ Monoclonal Antibody (8L93) 可用于 WB。

Anti-PROZ Monoclonal Antibody (8L93)
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产品介绍

生物活性
产品描述
Anti-PROZ Monoclonal Antibody (8L93) is a Mouse antibody targeting PROZ. Anti-PROZ Monoclonal Antibody (8L93) can be used in WB.
别名
PZ, protein Z
Ig Type
IgG1
克隆号
8L93
反应种属
Human
应用WB
推荐剂量
WB: 1/500-1/2000
抗体种类
Monoclonal
宿主来源Mouse
构建方式Hybridoma Monoclonal Antibody
纯化方式Purified by protein A or protein G
性状Liquid
缓冲液Ascitic fluid containing 0.03% sodium azide.
浓度1 mg/mL
研究背景PROZ protein Z, vitamin K-dependent plasma glycoprotein. It is 62 kDa large and 396 amino acids long. It has four domains: a gla-rich region, two EGF-like domains and a trypsin-like domain. It lacks the serine residue that would make it catalytically active as a serine protease. It is a member of the coagulation cascade, the group of blood proteins that leads to the formation of blood clots. It is vitamin K-dependent, and its functionality is therefore impaired in warfarin therapy. It is a glycoprotein. Although it is not enzymatically active, it is structurally related to several serine proteases of the coagulation cascade: factors VII, IX, X and protein C. The carboxyglutamate residues (which require vitamin K) bind protein Z to phospholipid surfaces. The main role of protein Z appears to be the degradation of factor Xa. This is done by protein Z-related protease inhibitor (ZPI), but the reaction is accelerated 1000-fold by the presence of protein Z. Oddly, ZPI also degrades factor XI, but this reaction does not require the presence of protein Z. In some studies, deficiency states have been associated with a propensity to thrombosis. Others, however, link it to bleeding tendency; there is no clear explanation for this, as it acts physiologically as an inhibitor, and deficiency would logically have led to a predisposition for thrombosis.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Purified recombinant fragment of PROZ expressed in E. Coli.
抗原种属
Human
基因名称
PROZ
基因ID
8858
蛋白名称
Vitamin K-dependent protein Z
Uniprot ID
P22891
化学信息
分子量Theoretical: 45 kDa.
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

  • 稀释 计算器
  • 配液 计算器
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