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Anti-Prostatic Acid Phosphatase Antibody (4E793)
还可以产品编号 TMAY-01380
Anti-Prostatic Acid Phosphatase Antibody (4E793) 是一种 Rabbit 抗体，靶向 Prostatic Acid Phosphatase。Anti-Prostatic Acid Phosphatase Antibody (4E793) 可用于 ELISA。
Anti-Prostatic Acid Phosphatase Antibody (4E793)
Anti-Prostatic Acid Phosphatase Antibody (4E793)
还可以产品编号 TMAY-01380
Anti-Prostatic Acid Phosphatase Antibody (4E793) 是一种 Rabbit 抗体，靶向 Prostatic Acid Phosphatase。Anti-Prostatic Acid Phosphatase Antibody (4E793) 可用于 ELISA。
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偶联与修饰
抗原信息
| 产品描述 | Anti-Prostatic Acid Phosphatase Antibody (4E793) is a Rabbit antibody targeting Prostatic Acid Phosphatase. Anti-Prostatic Acid Phosphatase Antibody (4E793) can be used in ELISA. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 4E793 |
| 交叉反应 | Human |
| 应用 | ELISA |
| 推荐剂量 | ELISA: 1:5000-1:10000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human Prostatic Acid Phosphatase / ACPP (rh Prostatic Acid Phosphatase / ACPP; TMPY-02155; NP_001127666.1; Met1-Lys382). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Prostatic acid phosphatase (PAP, or ACPP), also known as prostatic specific acid phosphatase (PSAP), is an enzyme produced by the prostate. As a non-specific phosphomonoesterase, Prostatic acid phosphatase is synthesized and secreted into seminal plasma under androgenic control. The enzyme is a dimer of molecular weight around 100 kDa. Prostatic acid phosphatase is a clinically important protein for its relevance as a biomarker of prostate carcinoma. Furthermore, it has a potential role in fertilization. The major action of PAP is to dephosphorylate macromolecules with the help of catalytic residues (His(12) and Asp(258)) that are located in the cleft between two domains. Cellular prostatic acid phosphatase (cPAcP), an authentic tyrosine phosphatase, is proposed to function as a negative growth regulator of prostate cancer (PCa) cells in part through its dephosphorylation of ErbB-2. cPAcP functions as a neutral protein tyrosine phosphatase (PTP) in prostate cancer cells and dephosphorylates HER-2/ErbB-2/Neu (HER-2: human epidermal growth factor receptor-2) at the phosphotyrosine (p-Tyr) residues. Injection of the secretory isoform of PAP has potent antinociceptive effects in mouse models of chronic pain. This enzyme exhibits ecto-5'-nucleotidase activity, is widely distributed, and implicated in the formation of chronic pain. Additionally, PAP could be a target molecule in specific immunotherapy for patients with nonprostate adenocarcinomas including colon and gastric cancers. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human Prostatic Acid Phosphatase / ACPP protein (TMPY-02155) |
| 抗原种属 | Human |
| 研究领域 | Phosphatases and Regulators |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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