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Anti-PRKDC Antibody (5G885)
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产品编号 TMAC-01156
别名 XRCC7, XRCC 7, Protein Kinase DNA Activated Catalytic Polypeptide, PRKDC, PKRDC, p460, p350, IMD26, HYRC1, HYRC 1, HYRC, Hyperradiosensitivity complementing 1, Hyper radiosensitivity of murine scid mutation, DNPK1, DNPK 1, DNA-PKcs, DNAPK catalytic subunit, DNAPK, DNA PK catalytic subunit, DNA dependent protein kinase catalytic subunit, complementing 1
Anti-PRKDC Antibody (5G885) 是一种 Rabbit 抗体，靶向 PRKDC。Anti-PRKDC Antibody (5G885) 可用于 WB,ICC/IF,IHC。
Anti-PRKDC Antibody (5G885)
Anti-PRKDC Antibody (5G885)
还可以产品编号 TMAC-01156 别名 XRCC7, XRCC 7, Protein Kinase DNA Activated Catalytic Polypeptide, PRKDC, PKRDC, p460, p350, IMD26, HYRC1, HYRC 1, HYRC, Hyperradiosensitivity complementing 1, Hyper radiosensitivity of murine scid mutation, DNPK1, DNPK 1, DNA-PKcs, DNAPK catalytic subunit, DNAPK, DNA PK catalytic subunit, DNA dependent protein kinase catalytic subunit, complementing 1
Anti-PRKDC Antibody (5G885) 是一种 Rabbit 抗体，靶向 PRKDC。Anti-PRKDC Antibody (5G885) 可用于 WB,ICC/IF,IHC。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,480 | 5日内发货 | |
| 100 μL | ¥ 2,495 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
化学信息
| 产品描述 | Anti-PRKDC Antibody (5G885) is a Rabbit antibody targeting PRKDC. Anti-PRKDC Antibody (5G885) can be used in WB,ICC/IF,IHC. |
| 别名 | XRCC7, XRCC 7, Protein Kinase DNA Activated Catalytic Polypeptide, PRKDC, PKRDC, p460, p350, IMD26, HYRC1, HYRC 1, HYRC, Hyperradiosensitivity complementing 1, Hyper radiosensitivity of murine scid mutation, DNPK1, DNPK 1, DNA-PKcs, DNAPK catalytic subunit, DNAPK, DNA PK catalytic subunit, DNA dependent protein kinase catalytic subunit, complementing 1 |
| Ig Type | IgG |
| 交叉反应 | Human,Mouse,Rat |
| 验证活性 | 1. Western blot analysis of DNA PKcs on different lysates using anti-DNA PKcs antibody at 1/1,000 dilution. Positive control: Lane 1: Hela, Lane 2: MCF-7. 2. ICC staining DNA PKcs in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 3. ICC staining DNA PKcs in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 4. ICC staining DNA PKcs in A549 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. |
| 应用 | |
| 推荐剂量 | WB: 1:1000-2000; IHC: 1:50-200; ICC/IF: 1:50-200 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | ProA affinity purified |
| 性状 | Liquid |
| 缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| 研究背景 | The phosphatidylinositol kinase (PIK) family members fall into two distinct subgroups. The first subgroup contains proteins such as the PI 3- and PI 4-kinases and the second group comprises the PIK-related kinases. The PIK-related kinases include Atm, DNA-PKCS and FRAP. These proteins have in common a region of homology at their carboxy termini that is not present in the PI 3- and PI 4-kinases. The Atm gene is mutated in the autosomal recessive disorder ataxia telangiectasia (AT) that is characterized by cerebellar degeneration (ataxia) and the appearance of dilated blood vessels (telangiectases) in the conjunctivae of the eyes. AT cells are hypersensitive to ionizing radiation, impaired in mediating the inhibition of DNA synthesis and they display delays in p53 induction. DNA-PK is a heterotrimeric DNA binding enzyme that is composed of a large subunit, DNA-PKCS, and two smaller subunits collectively known as Ku. The loss of DNA-PK leads to defects in DSB repair and V(D)J recombination. FRAP can autophosphorylate on serine and bind to rapamycin/FKBP. FRAP is also an upstream regulator of S6 kinase and has been implicated in the regulation of p27 and p21 expression. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein |
| Uniprot ID |
| 分子量 | Theoretical: 469 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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