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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-PRKAR1 Polyclonal Antibody

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货号 TMAB-11737

Anti-PRKAR1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 PRKAR1。Anti-PRKAR1 Polyclonal Antibody 可用于 WB。

Anti-PRKAR1 Polyclonal Antibody

Anti-PRKAR1 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-11737

Anti-PRKAR1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 PRKAR1。Anti-PRKAR1 Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

生物活性
产品描述
Anti-PRKAR1 Polyclonal Antibody is a Rabbit antibody targeting PRKAR1. Anti-PRKAR1 Polyclonal Antibody can be used in WB.
Ig Type
IgG
反应种属
Mouse (predicted:Human,Rat)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
组织特异性Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Three alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008].
抗原信息
免疫原
KLH conjugated synthetic peptide: human Protein Kinase A regulatory subunit I alpha
抗原种属
Human
基因名称
PRKAR1A
基因ID
5573
蛋白名称
cAMP-dependent protein kinase type I-alpha regulatory subunit
Uniprot ID
P10644
功能
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.
化学信息
分子量Theoretical: 43 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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