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Anti-presenilin 1 Polyclonal Antibody 3

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货号 TMAB-11728

Anti-presenilin 1 Polyclonal Antibody 3 是一种 Mouse 抗体，靶向 presenilin 1。Anti-presenilin 1 Polyclonal Antibody 3 可用于 IHC-P,IHC-Fr,IF。

Anti-presenilin 1 Polyclonal Antibody 3

Anti-presenilin 1 Polyclonal Antibody 3

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Rating icon 还可以
货号 TMAB-11728

Anti-presenilin 1 Polyclonal Antibody 3 是一种 Mouse 抗体，靶向 presenilin 1。Anti-presenilin 1 Polyclonal Antibody 3 可用于 IHC-P,IHC-Fr,IF。

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50 μL
¥ 1,160
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100 μL
¥ 1,960
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200 μL
¥ 2,795
5日内发货
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产品介绍

生物活性
产品描述
Anti-presenilin 1 Polyclonal Antibody 3 is a Mouse antibody targeting presenilin 1. Anti-presenilin 1 Polyclonal Antibody 3 can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Mouse (predicted:Human,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Mouse
亚细胞定位Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cell surface. Note=Bound to NOTCH1 also at the cell surface. Colocalizes with CDH1/2 at sites of cell-cell contact. Colocalizes with CTNNB1 in the endoplasmic reticulum and the proximity of the plasma membrane. Also present in azurophil granules of neutrophils.
组织特异性Expressed in a wide range of tissues including various regions of the brain, liver, spleen and lymph nodes.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008]
抗原信息
免疫原
KLH conjugated synthetic peptide: human presenilin 1
抗原种属
Human
基因名称
PSEN1
基因ID
5663
蛋白名称
Presenilin-1
Uniprot ID
P49768
功能
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis.
化学信息
分子量Theoretical: 34/52 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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