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Anti-Presenilin 1 Antibody (5C43)

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货号 TMAB-11730

Anti-Presenilin 1 Antibody (5C43) 是一种 Rabbit 抗体，靶向 Presenilin 1。Anti-Presenilin 1 Antibody (5C43) 可用于 FCM,IHC-P,IHC-Fr,IF。

Anti-Presenilin 1 Antibody (5C43)

Anti-Presenilin 1 Antibody (5C43)

一键复制产品信息
Rating icon 还可以
货号 TMAB-11730

Anti-Presenilin 1 Antibody (5C43) 是一种 Rabbit 抗体，靶向 Presenilin 1。Anti-Presenilin 1 Antibody (5C43) 可用于 FCM,IHC-P,IHC-Fr,IF。

规格价格库存数量
25 μL
¥ 790
5日内发货
50 μL
¥ 1,385
5日内发货
100 μL
¥ 2,485
5日内发货
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产品介绍

生物活性
产品描述
Anti-Presenilin 1 Antibody (5C43) is a Rabbit antibody targeting Presenilin 1. Anti-Presenilin 1 Antibody (5C43) can be used in FCM,IHC-P,IHC-Fr,IF.
Ig Type
IgG
克隆号
5C43
反应种属
Human,Mouse,Rat
应用FCMIHC-PIHC-FrIF
推荐剂量
FCM: 1:50-100; IHC-P: 1:50-200; IHC-Fr: 1:50-200; IF: 1:50-200
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cell surface. Note=Bound to NOTCH1 also at the cell surface. Colocalizes with CDH1/2 at sites of cell-cell contact. Colocalizes with CTNNB1 in the endoplasmic reticulum and the proximity of the plasma membrane. Also present in azurophil granules of neutrophils.
组织特异性Expressed in a wide range of tissues including various regions of the brain, liver, spleen and lymph nodes.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究背景Requires the presence of the other members of the gamma-secretase complex for protease activity.Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels.
抗原信息
免疫原
A synthesized peptide: human Presenilin 1
抗原种属
Human
基因名称
PSEN1
基因ID
5663
蛋白名称
Presenilin-1
Uniprot ID
P49768
功能
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis.
化学信息
分子量Theoretical: 53 kDa. Actual: 28 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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