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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-PPP2R2B/PP2A-B55 Polyclonal Antibody

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货号 TMAB-11679

Anti-PPP2R2B/PP2A-B55 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 PPP2R2B/PP2A-B55。Anti-PPP2R2B/PP2A-B55 Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。

Anti-PPP2R2B/PP2A-B55 Polyclonal Antibody

Anti-PPP2R2B/PP2A-B55 Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-11679

Anti-PPP2R2B/PP2A-B55 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 PPP2R2B/PP2A-B55。Anti-PPP2R2B/PP2A-B55 Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

生物活性
产品描述
Anti-PPP2R2B/PP2A-B55 Polyclonal Antibody is a Rabbit antibody targeting PPP2R2B/PP2A-B55. Anti-PPP2R2B/PP2A-B55 Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Mouse,Rat (predicted:Human,Chicken,Dog,Pig,Rabbit,Sheep)
应用WBIHC-PIHC-FrIF
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. cytoskeleton. Membrane and Cytoplasm. Mitochondrion. Mitochondrion outer membrane. Under basal conditions, localizes to both cytosolic and mitochondrial compartments. Relocalizes from the cytosolic to the mitochondrial compartment during apoptosis. Its targeting to the outer mitochondrial membrane (OMM) involves an association with import receptors of the TOM complex and is required to promote proapoptotic activity.
组织特异性Brain.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions, including division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the protein phosphatases. In general, the protein phosphatase (PP) holoenzyme is a trimeric complex composed of a regulatory subunit, a variable subunit and a catalytic subunit. Four major families of protein phosphatase catalytic subunits have been identified, designated PP1, PP2A, PP2B (calcineurin) and PP2C. An additional protein phosphatase catalytic subunit, PPX (also known as PP4) is a putative member of a novel PP family. The PP2A family comprises subfamily members PP2Aå and PP2A∫. The PP2A catalytic subunit associates with a variety of regulatory subunits. The B family of regulatory subunits (including B55, B56 and PR72/130 subfamilies) is believed to participate in substrate specificity and catalytic activity. PP2A-B55, also known as PP2A regulatory subunit subfamily B55 or PP2A-B1, is a B subfamily consisting of four B55 isoforms (Alpha,Beta, Gamma and Delta) encoded by four distinct genes.
抗原信息
免疫原
KLH conjugated synthetic peptide: human PPP2R2B/PP2A-B55
抗原种属
Human
基因名称
PPP2R2B
基因ID
5521
蛋白名称
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
Uniprot ID
Q00005
功能
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Within the PP2A holoenzyme complex, isoform 2 is required to promote proapoptotic activity (By similarity). Isoform 2 regulates neuronal survival through the mitochondrial fission and fusion balance.
化学信息
分子量Theoretical: 52 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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