购物车
全部删除
  • TargetMol
    您的购物车当前为空
前往下单页继续购物
顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Pokemon/ZBTB7A Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-11616

Anti-Pokemon/ZBTB7A Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Pokemon/ZBTB7A。Anti-Pokemon/ZBTB7A Polyclonal Antibody 可用于 WB。

Anti-Pokemon/ZBTB7A Polyclonal Antibody

Anti-Pokemon/ZBTB7A Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-11616

Anti-Pokemon/ZBTB7A Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Pokemon/ZBTB7A。Anti-Pokemon/ZBTB7A Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,790
5日内发货
库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单
大包装 & 定制
加入购物车
TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。
实验操作小课堂
常见问题解答
查看更多
资源下载:
产品操作手册

产品介绍

生物活性
产品描述
Anti-Pokemon/ZBTB7A Polyclonal Antibody is a Rabbit antibody targeting Pokemon/ZBTB7A. Anti-Pokemon/ZBTB7A Polyclonal Antibody can be used in WB.
Ig Type
IgG
反应种属
Mouse (predicted:Rat,Chicken,Dog,Pig,Cow,Sheep,Human)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus.
组织特异性Widely expressed. In normal thymus, expressed in medullary epithelial cells and Hassle's corpuscles (at protein level). In tonsil, expressed in squamous epithelium and germinal center lymphocytes (at protein level). Up-regulated in a subset of lymphomas, as well as in a subset of breast, lung, colon, prostate and bladder carcinomas (at protein level).
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Pokemon, the POK erythroid myeloid ontogenic factor, not only regulates the expression of many genes, but also plays an important role in cell tumorigenesis. To investigate the molecular mechanism regulating expression of the Pokemon gene in humans, its 5'-upstream region was cloned and analyzed. Transient analysis revealed that the Pokemon promoter is constitutive. Deletion analysis and a DNA decoy assay indicated that the NEG-U and NEG-D elements were involved in negative regulation of the Pokemon promoter, whereas the POS-D element was mainly responsible for its strong activity. Electrophoretic mobility shift assays suggested that the NEG-U, NEG-D and POS-D elements were specifically bound by the nuclear extract from A549 cells in vitro. Mutation analysis demonstrated that cooperation of the NEG-U and NEG-D elements led to negative regulation of the Pokemon promoter. Moreover, the NEG-U and NEG-D elements needed to be an appropriate distance apart in the Pokemon promoter in order to cooperate. Taken together, our results elucidate the mechanism underlying the regulation of Pokemon gene transcription, and also define a novel regulatory sequence that may be used to decrease expression of the Pokemon gene in cancer gene therapy.
抗原信息
免疫原
KLH conjugated synthetic peptide: human Pokemon
抗原种属
Human
基因名称
ZBTB7A
基因ID
51341
蛋白名称
Zinc finger and BTB domain-containing protein 7A
Uniprot ID
O95365
功能
Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals (By similarity). Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates E2F1-dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3'.
化学信息
分子量Theoretical: 63 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

  • 稀释 计算器
Related Tags: buy Anti-Pokemon/ZBTB7A Polyclonal Antibody | purchase Anti-Pokemon/ZBTB7A Polyclonal Antibody | Anti-Pokemon/ZBTB7A Polyclonal Antibody cost | order Anti-Pokemon/ZBTB7A Polyclonal Antibody | Anti-Pokemon/ZBTB7A Polyclonal Antibody molecular weight