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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-PMEL Antibody (7E548)

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货号 TMAB-11577

Anti-PMEL Antibody (7E548) 是一种 Rabbit 抗体，靶向 PMEL。Anti-PMEL Antibody (7E548) 可用于 WB,IHC-P,IHC-Fr,IF。

Anti-PMEL Antibody (7E548)

Anti-PMEL Antibody (7E548)

一键复制产品信息
Rating icon 还可以
货号 TMAB-11577

Anti-PMEL Antibody (7E548) 是一种 Rabbit 抗体，靶向 PMEL。Anti-PMEL Antibody (7E548) 可用于 WB,IHC-P,IHC-Fr,IF。

规格价格库存数量
25 μL
¥ 795
5日内发货
50 μL
¥ 1,395
5日内发货
100 μL
¥ 2,490
5日内发货
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产品介绍

生物活性
产品描述
Anti-PMEL Antibody (7E548) is a Rabbit antibody targeting PMEL. Anti-PMEL Antibody (7E548) can be used in WB,IHC-P,IHC-Fr,IF.
Ig Type
IgG
克隆号
7E548
反应种属
Human
应用WBIHC-PIHC-FrIF
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Secreted and Endoplasmic reticulum membrane. Golgi apparatus. Melanosome. Endosome > multivesicular body. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Localizes predominantly to intralumenal vesicles (ILVs) within multivesicular bodies. Associates with ILVs found within the lumen of premelanosomes and melanosomes and particularly in compartments that serve as precursors to the striated stage II premelanosomes.Target information above from: UniProt accession P40967 The UniProt Consortium The Universal Protein Resource (UniProt) in 2010 Nucleic Acids Res. 38:D142-D148 (2010) .
组织特异性Preferentially expressed in melanomas. Some expression was found in dysplastic nevi. Not found in normal tissues nor in carcinomas. Normally expressed at low levels in quiescent adult melanocytes but overexpressed by proliferating neonatal melanocytes and during tumor growth.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究背景Plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures. Release of the soluble form, ME20-S, could protect tumor cells from antibody mediated immunity.
抗原信息
免疫原
A synthesized peptide: human PMEL
抗原种属
Human
基因名称
PMEL
基因ID
6490
蛋白名称
Melanocyte protein PMEL
Uniprot ID
P40967
功能
Plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures. Release of the soluble form, ME20-S, could protect tumor cells from antibody mediated immunity.
化学信息
分子量Theoretical: 70 kDa. Actual: 100 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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