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顶部产品介绍偶联与修饰抗原信息储存和溶解信息计算器

Anti-PLK1 Monoclonal Antibody (2Y916)

Synonyms: STPK13, PLK
货号 TMAT-1115 一键复制产品信息
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Anti-PLK1 Monoclonal Antibody (2Y916) 是一种 Mouse 抗体，靶向 PLK1。Anti-PLK1 Monoclonal Antibody (2Y916) 可用于 IF。

Anti-PLK1 Monoclonal Antibody (2Y916)

一键复制产品信息
Rating icon 还可以
货号 TMAT-1115

别名 STPK13, PLK

Anti-PLK1 Monoclonal Antibody (2Y916) 是一种 Mouse 抗体，靶向 PLK1。Anti-PLK1 Monoclonal Antibody (2Y916) 可用于 IF。

Anti-PLK1 Monoclonal Antibody (2Y916)
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产品介绍

生物活性
产品描述
Anti-PLK1 Monoclonal Antibody (2Y916) is a Mouse antibody targeting PLK1. Anti-PLK1 Monoclonal Antibody (2Y916) can be used in IF.
别名
STPK13, PLK
Ig Type
IgG1
克隆号
2Y916
反应种属
Human
应用IF
推荐剂量
IF: 1/50-1/200
抗体种类
Monoclonal
宿主来源Mouse
构建方式Hybridoma Monoclonal Antibody
纯化方式Purified by protein A or protein G
性状Liquid
缓冲液PBS with 0.05% sodium azide
浓度1 mg/mL
研究背景PLK1 is critical for the initiation of centrosome maturation. Polo-like kinases (PLKs) are a family of four serine/threonine protein kinases that are critical regulators of cell cycle progression, mitosis, cytokinesis, and the DNA damage response. PLK1, -2 and -3 are ubiquitously expressed, whereas PLK4 is restricted to a few tissues including the testes and the thymus. The mRNA and protein expression of PLK1, -2 and -4 are coordinately regulated during cell cycle progression, but PLK3 levels are independent of the other three family members. Furthermore, PLK3 is a much more stable protein than PLK1, -2 or -4. PLK1 is the most well characterized member of this family and strongly promotes the progression of cells through mitosis. During the various stages of mitosis PLK1 localizes to the centrosomes, kinetochores and central spindle. PLKs are dysregulated in a variety of human cancers. PLK1 overexpression correlates with cellular proliferation and poor prognosis. PLK2 and PLK3 are involved in checkpoint-mediated cell cycle arrest to ensure genetic stability. Loss-of-function mutations in these enzymes can lead to oncogenic transformation.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Purified recombinant fragment of human PLK1 (AA: 331-508) expressed in E. Coli.
抗原种属
Human
基因名称
PLK1
基因ID
5347
蛋白名称
Serine/threonine-protein kinase PLK1
Uniprot ID
P53350
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

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  • 配液 计算器
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