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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Plexin A1 Polyclonal Antibody

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货号 TMAB-11547

Anti-Plexin A1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Plexin A1。Anti-Plexin A1 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-Plexin A1 Polyclonal Antibody

Anti-Plexin A1 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-11547

Anti-Plexin A1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Plexin A1。Anti-Plexin A1 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍

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产品描述
Anti-Plexin A1 Polyclonal Antibody is a Rabbit antibody targeting Plexin A1. Anti-Plexin A1 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Rat (predicted:Human,Mouse,Dog,Pig,Cow,Horse,Sheep)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:400-800; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cell membrane (Probable); Single-pass type I membrane protein.
组织特异性Detected in fetal brain, lung, liver and kidney.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Plexins are a family of large integral membrane proteins that complex with neuropilins to form semaphorin co-receptors. The extracellular region of plexins contain a semaphorin domain, multiple glycine rich motifs, and MET related sequences. The cytoplasmic region contains a Sex/Plexin domain and putative tyrosine phosphorylation sites that mediate signal transduction after activation. This region in Plexin A1 binds the RhoGTPases, Rnd1 and RhoD. Recruitment of Rnd1 has been implicated in the cytoskeletal collapse that occurs after semaphorin mediated activation of Plexin A1, while RhoD may block this collapsing activity through interaction with the cytoplasmic region of Plexin A1. The expression of Plexin A1, along with the co receptor Neuropilin 1, is upregulated in neurons after central nervous system injury. The axons from these neurons cannot cross semaphorin 3A containing regions at the site of injury. Thus, semaphorin 3A and its co-receptors, Plexin A1 and Neuropilin 1, may have significant roles in axon regeneration after neuronal injury.
抗原信息
免疫原
KLH conjugated synthetic peptide: human Plexin A1
抗原种属
Human
基因名称
PLXNA1
基因ID
5361
蛋白名称
Plexin-A1
Uniprot ID
Q9UIW2
功能
Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.
化学信息
分子量Theoretical: 206 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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