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Anti-PIRH2 Monoclonal Antibody (1K622) 是一种 Mouse 抗体,靶向 PIRH2。Anti-PIRH2 Monoclonal Antibody (1K622) 可用于 WB,IHC,IF,FCM。
别名 ZNF363, ZCHY, RNF199, RCHY1, PRO1996, CHIMP, ARNIP
Anti-PIRH2 Monoclonal Antibody (1K622) 是一种 Mouse 抗体,靶向 PIRH2。Anti-PIRH2 Monoclonal Antibody (1K622) 可用于 WB,IHC,IF,FCM。

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| 产品描述 | Anti-PIRH2 Monoclonal Antibody (1K622) is a Mouse antibody targeting PIRH2. Anti-PIRH2 Monoclonal Antibody (1K622) can be used in WB,IHC,IF,FCM. |
| 别名 | ZNF363, ZCHY, RNF199, RCHY1, PRO1996, CHIMP, ARNIP |
| Ig Type | IgG1 |
| 克隆号 | 1K622 |
| 反应种属 | Human,Rat |
| 应用 | WBIHCIFFCM |
| 推荐剂量 | WB: 1/500-1/2000; IHC: 1/200-1/1000; IF: 1/200-1/1000; FCM: 1/200-1/400 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | Hybridoma Monoclonal Antibody |
| 纯化方式 | Purified by protein A or protein G |
| 性状 | Liquid |
| 缓冲液 | PBS with 0.05% sodium azide. |
| 浓度 | 1 mg/mL |
| 研究背景 | PIRH2 (P53 induced RING-H2 protein), also known as RCHY1, it forms dimers through its N- and C-terminus in cells. The Pirh2 has ubiquitin-protein ligase activity and it binds with p53 and promotes the ubiquitin-mediated proteosomal degradation of p53. The Pirh2 is oncogenic because loss of p53 function contributes directly to malignant tumor development. Pirh2 expression decreases the level of p53, and a decrease of endogenous Pirh2 expression increases p53 levels. Pirh2 is therefore considered, together with MDM2, to act as a negative regulator of p53 function. |
| 偶联 | Unconjugated |
| 免疫原 | Purified recombinant fragment of human Pirh2 expressed in E. Coli. |
| 抗原种属 | Human |
| 基因名称 | RCHY1 |
| 基因ID | |
| 蛋白名称 | RING finger and CHY zinc finger domain-containing protein 1 |
| Uniprot ID |
| 分子量 | Theoretical: 30; 60 kDa (homodimer). |
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |