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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-PINX-1 Polyclonal Antibody

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货号 TMAB-11462

Anti-PINX-1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 PINX-1。Anti-PINX-1 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF,FCM。

Anti-PINX-1 Polyclonal Antibody

Anti-PINX-1 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-11462

Anti-PINX-1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 PINX-1。Anti-PINX-1 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF,FCM。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍

生物活性
产品描述
Anti-PINX-1 Polyclonal Antibody is a Rabbit antibody targeting PINX-1. Anti-PINX-1 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF,FCM.
Ig Type
IgG
反应种属
Mouse (predicted:Human,Rat,Pig,Cow,Horse)
应用IHC-PIHC-FrIFFCM
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; FCM: 2μg/Test
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus.
组织特异性Ubiquitous; expressed at low levels.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景PINX1 is a ubiquitously expressed protein that localizes to nucleoli and telomere speckles. PINX1 contains one G-patch domain and one telomeric inhibiting domain (TID) at its C-terminus. PINX1 interacts with the telomere protein TRF1 and the telomerase reverse transcriptase TERT. The TID domain of PINX1 specifically interacts with TERT and functions to inhibit its activity, thus participating in the regulation of telomerase activity. Overexpression of PINX1 leads to shortened telomeres, further supporting an inhibitory role of PINX1 on telomerase activity. The depletion of PINX1 significantly increases telomerase activity and may lead to tumorigenicity of cancer cells. This suggests that PINX1 acts as a tumor suppressor and can inhibit cell proliferation. In addition, PINX1 is involved in nucleolar RNA maturation.
抗原信息
免疫原
KLH conjugated synthetic peptide: human PINX-1
抗原种属
Human
基因名称
PINX1
基因ID
54984
蛋白名称
PIN2/TERF1-interacting telomerase inhibitor 1
Uniprot ID
Q548A5
功能
Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor.
化学信息
分子量Theoretical: 37 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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