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Anti-Phospho-Wee1 (Ser53) Polyclonal Antibody

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货号 TMAB-11417

Anti-Phospho-Wee1 (Ser53) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-Wee1 (Ser53)。Anti-Phospho-Wee1 (Ser53) Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。

Anti-Phospho-Wee1 (Ser53) Polyclonal Antibody

Anti-Phospho-Wee1 (Ser53) Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-11417

Anti-Phospho-Wee1 (Ser53) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-Wee1 (Ser53)。Anti-Phospho-Wee1 (Ser53) Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-Wee1 (Ser53) Polyclonal Antibody is a Rabbit antibody targeting Phospho-Wee1 (Ser53). Anti-Phospho-Wee1 (Ser53) Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Human,Mouse,Rat (predicted:Chicken,Dog,Pig,Cow,Rabbit)
应用WBIHC-PIHC-FrIF
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase.
抗原信息
免疫原
KLH conjugated synthesised phosphopeptide: human Wee1 around the phosphorylation site of Ser53
抗原种属
Human
基因名称
WEE1
基因ID
7465
蛋白名称
Wee1-like protein kinase
Uniprot ID
P30291
功能
Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation
化学信息
分子量Theoretical: 72 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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