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Anti-Phospho-VAV1 (Tyr174) Polyclonal Antibody

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货号 TMAB-11411

Anti-Phospho-VAV1 (Tyr174) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-VAV1 (Tyr174)。Anti-Phospho-VAV1 (Tyr174) Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-Phospho-VAV1 (Tyr174) Polyclonal Antibody

Anti-Phospho-VAV1 (Tyr174) Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-11411

Anti-Phospho-VAV1 (Tyr174) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-VAV1 (Tyr174)。Anti-Phospho-VAV1 (Tyr174) Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,165
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100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-VAV1 (Tyr174) Polyclonal Antibody is a Rabbit antibody targeting Phospho-VAV1 (Tyr174). Anti-Phospho-VAV1 (Tyr174) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Rat (predicted:Human,Mouse,Dog,Pig,Horse)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
组织特异性Widely expressed in hematopoietic cells but not in other cell types.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012].
抗原信息
免疫原
KLH conjugated Synthesised phosphopeptide: human VAV1 around the phosphorylation site of Tyr174
抗原种属
Human
基因名称
VAV1
基因ID
7409
蛋白名称
Proto-oncogene vav
Uniprot ID
P15498
功能
Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.
化学信息
分子量Theoretical: 98 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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