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Anti-Phospho-VASP (Ser239) Polyclonal Antibody 2

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产品编号 TMAB-11410

Anti-Phospho-VASP (Ser239) Polyclonal Antibody 2 是一种 Rabbit 抗体,靶向 Phospho-VASP (Ser239)。Anti-Phospho-VASP (Ser239) Polyclonal Antibody 2 可用于 WB。

Anti-Phospho-VASP (Ser239) Polyclonal Antibody 2

Anti-Phospho-VASP (Ser239) Polyclonal Antibody 2

一键复制产品信息
Rating icon 还可以
产品编号 TMAB-11410

Anti-Phospho-VASP (Ser239) Polyclonal Antibody 2 是一种 Rabbit 抗体,靶向 Phospho-VASP (Ser239)。Anti-Phospho-VASP (Ser239) Polyclonal Antibody 2 可用于 WB。

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50 μL
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¥ 1,960
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200 μL
¥ 2,780
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产品介绍

生物活性
产品描述
Anti-Phospho-VASP (Ser239) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-VASP (Ser239). Anti-Phospho-VASP (Ser239) Polyclonal Antibody 2 can be used in WB.
Ig Type
IgG
交叉反应
Mouse (predicted:Human,Rat,Dog,Cow)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cell projection, lamellipodium membrane. Cell projection, filopodium membrane. Note=Targeted to stress fibers and focal adhesions through interaction with a number of proteins including MRL family members. Localizes to the plasma membrane in protruding lamellipodia and filopodial tips. Stimulation by thrombin or PMA, also translocates VASP to focal adhesions. Localized along the sides of actin filaments throughout the peripheral cytoplasm under basal conditions.
组织特异性Highly expressed in platelets.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG. [provided by RefSeq, Jul 2008]
抗原信息
免疫原
KLH conjugated synthesised phosphopeptide: human VASP around the phosphorylation site of Ser239
抗原种属
Human
基因名称
VASP
基因ID
蛋白名称
Vasodilator-stimulated phosphoprotein
Uniprot ID
功能
Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation.
化学信息
分子量Theoretical: 40 kDa.
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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