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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Phospho-TSC1 (Ser505) Polyclonal Antibody

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货号 TMAB-11398

Anti-Phospho-TSC1 (Ser505) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-TSC1 (Ser505)。Anti-Phospho-TSC1 (Ser505) Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。

Anti-Phospho-TSC1 (Ser505) Polyclonal Antibody

Anti-Phospho-TSC1 (Ser505) Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-11398

Anti-Phospho-TSC1 (Ser505) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-TSC1 (Ser505)。Anti-Phospho-TSC1 (Ser505) Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-TSC1 (Ser505) Polyclonal Antibody is a Rabbit antibody targeting Phospho-TSC1 (Ser505). Anti-Phospho-TSC1 (Ser505) Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Human,Mouse (predicted:Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit)
应用WBIHC-PIHC-FrIF
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Membrane; Peripheral membrane protein. Note=At steady state found in association with membranes.
组织特异性Highly expressed in skeletal muscle, followed by heart, brain, placenta, pancreas, lung, liver and kidney. Also expressed in embryonic kidney cells.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder characterized by mental retardation and the widespread development of distinctive tumors termed hamartomas. Two different genetic loci have been linked to TSC; one of these loci, the tuberous sclerosis-2 gene (TSC2), encodes a protein called tuberin and the other loci, tuberous sclerosis-1 gene (TSC1), encodes a protein called hamartin. Tuberin and hamartin interact with each other forming a cystoplasmic complex. Hamartin interacts with the ezrin-radixin-moesin (ERM) family of actin-binding proteins and inhibition of hamartin activity results in loss of cell adhesion. Hamartin is present in most adult tissues with strong expression in brain, heart, and kidney.
抗原信息
免疫原
KLH conjugated Synthesised phosphopeptide: human TSC1 around the phosphorylation site of Ser505
抗原种属
Human
基因名称
TSC1
基因ID
7248
蛋白名称
Hamartin
Uniprot ID
Q92574
功能
In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Seems not to be required for TSC2 GAP activity towards RHEB. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling.
化学信息
分子量Theoretical: 128 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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