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Anti-Phospho-TNK1 (Tyr277) Polyclonal Antibody 2

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货号 TMAB-11383

Anti-Phospho-TNK1 (Tyr277) Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Phospho-TNK1 (Tyr277)。Anti-Phospho-TNK1 (Tyr277) Polyclonal Antibody 2 可用于 WB。

Anti-Phospho-TNK1 (Tyr277) Polyclonal Antibody 2

Anti-Phospho-TNK1 (Tyr277) Polyclonal Antibody 2

一键复制产品信息
Rating icon 还可以
货号 TMAB-11383

Anti-Phospho-TNK1 (Tyr277) Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Phospho-TNK1 (Tyr277)。Anti-Phospho-TNK1 (Tyr277) Polyclonal Antibody 2 可用于 WB。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-TNK1 (Tyr277) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-TNK1 (Tyr277). Anti-Phospho-TNK1 (Tyr277) Polyclonal Antibody 2 can be used in WB.
Ig Type
IgG
反应种属
Mouse (predicted:Human,Rat,Dog,Pig,Horse,Rabbit,GuineaPig)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Membrane; Peripheral membrane protein.
组织特异性Expressed in all umbilical cord blood, bone marrow and adult blood cell sub-populations and in several leukemia cell lines. Highly expressed in fetal blood, brain, lung, liver and kidney. Detected at lower levels in adult prostate, testis, ovary, small intestine and colon. Not expressed in adult lung, liver, kidney or brain.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Tnk1 is a nonreceptor protein tyrosine kinase (NRPTK) and a new member of the Ack family of NRPTKs. Tnk1 is a ubiquitously expressed 47-kDa protein with autotyrosine kinase activity that is developmentally regulated during embryogenesis. Tnk1 is also upregulated following IL3 withdrawal from factor-dependent murine NSF/N1.H7 cells that undergo apoptosis, suggesting a role in growth inhibition. Data support a negative regulatory role for Tnk1 in regulating the Ras-Raf1-MAPK growth pathway by a mechanism that requires its autotyrosine kinase activity.
抗原信息
免疫原
KLH conjugated synthesised phosphopeptide: human TNK1 around the phosphorylation site of Tyr277
抗原种属
Human
基因名称
TNK1
基因ID
8711
蛋白名称
Non-receptor tyrosine-protein kinase TNK1
Uniprot ID
Q13470
功能
Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction.
化学信息
分子量Theoretical: 73 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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